A COMPARASON OF EFFECTS OF KETAMINE-DEXMEDETOMIDINEVERSUS FENTANYL-PROPOFOL IN PATIENTS UNDERGOING CARDIACSURGERY FOR MYOCARDIAL PROTECTIO
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/07/071613
- Lead Sponsor
- SMS Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Informed written consent for the study
2. All patients will be American Society of Anaesthesiologists physical status II-III.
3. Aged between 18 and 70 years.
4. Weight between 40 and 70 kg.
5. BMI less than 30.
6. New York Heart Association classification of cardiac function II-III,
7. Ejection fraction greater than 40%
Exclusion Criteria
1. Patient should not part of any other study.
2. Non cooperative patient.
3. Patient with history of acute myocardial infarction.
4. Elevated levels of circulating cardiac troponin
5. History of endocrine, metabolic, neurological and psychotic disorder
6. History of previous unusual response to ketamine, dexmedotomidine, fentanyl,
propofol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess and compare the Plasma cardiac troponin-I, CK-MB level, serum cortisol level in Ketamine-dexmedetomidine group and fentanyl-propofol groupTimepoint: Blood samples will be drawn before induction, 4 hours after aortic cross clamping and 24 hours after aortic cross clamping.
- Secondary Outcome Measures
Name Time Method IlTimepoint: NI