Screening of Oral Cancer

Not yet recruiting

• Conditions: Malignant neoplasms of lip, oral cavity and pharynx,

• Registration Number: CTRI/2021/07/035059
• Lead Sponsor: Department of Science and Technology

Brief Summary

The spectroscopy based techniques are emerging up as promising techniques for the early detection and screening of different types of cancers (e.g. Oral, breast, cervical etc.). Among them, Surface Enhanced Raman Spectroscopy(SERS) based analysis of body fluids can represent an alternative of tissue biopsy which is called as optical liquid biopsy. This single center observational study mainly aims the development of a portable device based on optical SERS spectroscopic technique for the molecular fingerprinting of microliters of diluted body fluids such as saliva and blood for detecting oral cancer at an earlier stage. Also, the superhydrophobic plasmonic array offers some advantages such as minimum requirement of sample as well as the concentration enhancement of analytes. In addition to this, the usage of different multivariate statistical analysis tools will help us differentiating the spectroscopic data into different datasets. The developed system for the early screening of oral cancer will be highly beneficial to the society to bring down the cervical cancer mortality rate.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-08
• Last Update Posted: 2021-06-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 159

Inclusion Criteria

All above 18 years of age and having malignant or benign type of oral cancer are included.

Exclusion Criteria

• All patients below age 18 are excluded.
• Also, the subjects having co-morbidity conditions which does not allow biopsy will be excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
This study focuses on the development of a portable device based on optical SERS spectroscopic technique for the molecular fingerprinting of microliters of diluted saliva for the detecting oral cancer at an earlier stage. The usage of different multivariate statistical analysis tools will be helpful in analyzing the Raman spectroscopic data thereby differentiating them into different sets.	2 years

Trial Locations

Locations (1)

Manipal College Of Dental Sciences; 🇮🇳 Udupi, KARNATAKA, India

Manipal College Of Dental Sciences

🇮🇳Udupi, KARNATAKA, India

Dr Keerthilatha M Pai

Principal investigator

9845637938

keerthilatha.pai@manipal.edu