Clinical Study To Evaluate The Effect Of Yavaksharadi Yoga In Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is a broad term which describe the build-upof excessive fat in the liver cell, in the absence of alcohol intake (<20gm/day for women and<30 gm/day for men). In the majority of patients, NAFLD is commonly associated withmetabolic co-morbidities such as obesity, diabetes mellitus and dyslipidaemia. Yavaksharadiyoga which contains Yava kshara, Pippali, Vidalavana and Putika (Chiruvilwa) kashaya is one among the formulations mentioned in Yogaratnakara for Yakrit rogas. The drugs used mighthelpful in normalising the metabolic functions of liver. The present study is proposed to evaluate the effect of Yavaksharadi yoga in Non-alcoholic fatty liver disease.Study design will be clinical trial, done among 30 participants for a period of 45 days in the age group of 20-60 years. Participants diagnosed as per diagnostic criteria and satisfying the inclusion criteria will be selected conveniently from OPD and IPD of Pankajakasthuri Ayurveda Medical College and PG Centre. Subjects will be given the prepared medicine 500 mg morning 1 hour before food with Putika (Chiruvilwa) kashaya as Anupana for a period of30 days. Assessment of Objective criteria i.e., USG and LFT will be done before treatment and on 46th day, Assessment of subjective criteria like Appetite, Anorexia, Fatigue, Aching pain on right upper quadrant and Pedal oedema will be done before treatment,31st and 46th day. Nospecial diet modification or lifestyle change is advised during this period. The data will be analysed using the appropriate statistical tests.

Null hypothesis: Yavaksharadi yoga has no significant effect in Non-alcoholic fatty liver disease. Alternate hypothesis: Yavaksharadi yoga has a significant effect in Non-alcoholic fatty liver disease