Steroid and Anticoagulant Therapy in covid19

Not Applicable

Completed

• Conditions: Pneumonia, Viral
• Interventions: Procedure: steroid and anticoagulants according to different protocols.

• Registration Number: NCT05021588
• Lead Sponsor: Assiut University

Brief Summary

As COVID-19 has neither standard treatment protocol nor guidelines, there are many treatment protocols foranti-inflammatory corticosteroids and anti-coagulations for severe COVID-19 pneumonia patients. This study aimed to assess the most suitable modality in this high-risk group.

Methods: A prospective, experimental study design was adopted, that included 123 severe COVID-19 pneumonia patientsadmitted at Assiut UniversityHospital from April 10th, 2020, to September10th, 2020. Patients were divided into 3 groups according to a combined corticosteroid and anticoagulants therapy protocols. Group A included 32 patients, group B included 45 patients, and group C included 46 patients. Assessment of cases was conducted according to the treatment type and duration, weaning duration from oxygen therapy, length of hospital and ICU stay, and complications during treatment.Three months follow up after discharge was performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-12
• Primary Completion: 2020-08-02
• Study Completion: 2020-09-10
• Status Verified: 2021-08
• Study First Submitted: 2021-08-16
• Study First Submitted QC: 2021-08-23
• Last Update Submitted: 2021-08-23
• Study First Posted: 2021-08-25
• Last Update Posted: 2021-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 123

Inclusion Criteria

• respiratory distress [respiratory rate (RR) >30 breaths/min at rest], mean oxygen saturation ≤93%,ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) ≤300 mmHg,>50% lung involvement on imaging within 24 to 48 hours of admission

Exclusion Criteria

• pnumonia not caused by covid19

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A:dexamethasone	steroid and anticoagulants according to different protocols.	-
Group B: prednisolone or methyl prednisolone according to D-dimer levels.	steroid and anticoagulants according to different protocols.	-
Group C: prednisolone or methylprednisolone and anticoagulants according to the flexible protocol.	steroid and anticoagulants according to different protocols.	-

Primary Outcome Measures

Name	Time	Method
Outcome of patients after corticosteroids and anti-coagulants for severe COVID-19 pneumonia	5 months

Trial Locations

Locations (1)

Marwarady; 🇪🇬 Asyut, Egypt