Compare the Skin Barrier Repair Function of Two Ceramide Containing Moisturizers

Not Applicable

• Conditions: CeraVe Moisturising Lotion
• Interventions: Drug: Ceramides

• Registration Number: NCT04185025
• Lead Sponsor: Peking University First Hospital

Brief Summary

This study aims to evaluate the improvement of CeraVe moisturising lotion on the cuticle moisture of dry skin and barrier repair function.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-20
• Status Verified: 2019-11
• Study First Submitted: 2019-11-29
• Study First Submitted QC: 2019-11-29
• Last Update Submitted: 2019-11-29
• Primary Completion: 2019-12
• Study First Posted: 2019-12-04
• Last Update Posted: 2019-12-04
• Study Completion: 2020-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Those who volunteer to participate in the trial, sign the informed consent, be able to cooperate with follow-up observation, and conduct the trial according to the guidance of the doctor.
• Dry skin subjects with symmetrical distribution of forearm flexion diagnosed by a doctor.
• Those who are 30-80 years old, male or female.
• Those with good compliance who can not use other external drugs during the entire observation period.

Exclusion Criteria

• Those who do not sign the informed consent.
• Those with the history of allergies to test product and control product ingredients.
• Those who received or are receiving medical or physical therapy for any skin or systemic disease recently (≤3 months)
• Those who have a large amount of exudation in the acute phase or who are infected at the test site.
• Female subjects who are preparing for pregnancy, pregnancy, lactation, or within six months after delivery.
• Those who participate in clinical trials of other moisturizing products or emollients.
• Those who are taking other oral medicines that affect the skin condition.
• Those who the investigator considers unsuitable for other reasons.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CeraVe Moisturising Lotion	Ceramides	-
Half Mu ceramide body milk	Ceramides	-

Primary Outcome Measures

Name	Time	Method
Self-assessment from patients	17 days	The patients fill out questionnaires and score erythema, desquamation, dryness, itching, and cleft palate on both sides of the calves (0 = none, 1 = light, 2 = medium, 3 = severe).

Secondary Outcome Measures

Name	Time	Method
The loss of transdermal water	0 day, 1 day, 7 days, 14 days, 17 days	The percutaneous water loss value of the test site is measured continuously in an open chamber with Tewameter (TM300, Courage and Khazaka, Germany), and the measurement is performed 3 times continuously. The average value is taken after the value is stable.
Cuticle moisture	0 day, 1 day, 7 days, 14 days, 17 days	The water content in the stratum corneum of the test site is measured 5 times with Corneometer (CM825, Course and Khazaka, Germany) and the average value is taken.

Trial Locations

Locations (1)

Peking University First Hospital; 🇨🇳 Beijing, China