Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections

Completed

• Conditions: Neck Abscess; Inflammation; Infection; Mediastinitis
• Interventions: Other: treatment of infection

• Registration Number: NCT04865003
• Lead Sponsor: Clinical Center of Vojvodina

Brief Summary

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections.

Detailed Description

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections. The study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of multispace DNI with or without DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment during 7-years period. The data were obtained from patient medical records.

Study Timeline

• Study Start: 2014-01-01
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-04
• Study First Submitted: 2021-04-14
• Study First Submitted QC: 2021-04-27
• Last Update Submitted: 2021-04-27
• Study First Posted: 2021-04-29
• Last Update Posted: 2021-04-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 289

Inclusion Criteria

• patients admitted to the hospital due to deep neck infection affecting two or more spaces with or without descending necrotizing medioastinitis
• complete diagnosis and treatment data available from medical charts

Exclusion Criteria

• incomplete medical data
• infection confined to one deep neck space
• patients treated under local anesthesia
• patients with superficial skin infections
• iatrogenic infections
• infected tumors

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
DNI group	treatment of infection	patients with infection of two or more deep neck spaces (DNI group)
DNI + DNM group	treatment of infection	patients with infection of two or more deep neck spaces with secondary descending necrotizing mediastinitis (DNI + DNM group)

Primary Outcome Measures

Name	Time	Method
Incidence of mediastinitis	Within 6 hours of admission	Neck and chest computed tomography (CT)

Secondary Outcome Measures

Name	Time	Method
Average number of hospital days	Through study completion, an average of one month	Comparison of average number of hospital days in DNI and DNM
Number of infected deep neck spaces	Within 6 hours of admission	Neck and chest computed tomography (CT)
Microbiological findings in DNI and DNM	Within 1 week of admission	Prevalence of microorganisms in mediastinitis
Incidence of complications	Within 30 days from admission	Complications among DNI and DNI+DNM groups