Colorectal adenoma-carcinoma sequence rediscovered: interaction of human gut microbiota and local immune system in health and carcinogenesis in adult patients

Vilnius University Faculty of Medicine0 个研究点目标入组 54 人开始时间: 2024年8月12日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Exposure groups:
•(1)Patients with histologically confirmed dysplastic colorectal lesion: early and advanced-adenoma, carcinoma in situ or adenocarcinoma (advanced adenomas are defined as those with high-grade dysplasia, villous or tubulovillous histology, equal to or greater than 1 cm in diameter);
•(2)Adult patients;
•(3)Written informed consent.
•Control (healthy) group:
•(1) Healthy patients (without any polypoid lesions found during screening colonoscopy)
•(2) Adult patients;
•(3)Written informed consent.

•Exclusion criteria
•(1)Patients under the age of 18 years;
•(2)Confirmed serrated (sessile serrated (SSA), traditional serrated adenomas (TSA)) or hyperplastic polyps or non-polypoid lesions;
•(3)Signs of colorectal tumor obturating the lumen of the bowel which would limit complete colonoscopy;
•(4)Suffer from other gastrointestinal tumors;
•(5)Pregnancy;
•(6)Previous colon resection;
•(7)History of surgery disrupting gastrointestinal tract integrity;
•(8)History of inflammatory bowel disease (ulcerative, Crohn’s, radiation-induced, or infectious colitis or other previous chronic inflammatory illnesses);
•(9)Familial adenomatous polyposis (FAP) or other hereditary colon syndromes;
•(10)Clinically significant immunodeficiency;
•(11)Evidence of infection;
•(12)During the last year patient had:
•-suffered from Cl. difficile colitis or was a carrier of Cl. difficile; suffered from salmonellosis or other gastrointestinal infection;
•-a long-term (> 6 months) use or recently completed therapeutic antibiotic course within the last month;
•-corticosteroid and/or immunosuppressant therapy;
•-received chemo- or radiation therapy in the abdomen and/or pelvis chemotherapy;
•-regular use (> 3 months) of pre-/pro-/(sin)biotics and/or statins;
•-a long-term (> 6 months) use of proton pump inhibitors;
•(13)Patients who cannot undergo colonoscopy on time and cannot cooperate fully.

发起方

Vilnius University Faculty of Medicine