Comparison of safety and effectiveness of continuous and cycled blue light therapy of newborns with jaundice
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Neonatal Jaundice
- Registration Number
- CTRI/2018/01/011072
- Lead Sponsor
- Sasi Bhushan Gottimukkala
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 176
Inclusion Criteria
Intermittent vs Continuous Phototherapy
Exclusion Criteria
Neonates with bilirubin in the exchange transfusion range, as per AAP charts
Significant haemolytic jaundice (One or more of the following
Low haemoglobin for gestational age
Direct antibody test positive
Rh incompatilibility setting with antenatal investigations showing evidence of isoimmunisation like Indirect antibody test positive, elevated middle cerebral peak systolic velocity in fetal Doppler USG, presence of hepatosplenomegaly and hydrops in foetal ultrasound)
Already received > 5 hours of phototherapy
Neonates with major congenital anomalies
Neonates with birth asphyxia
Significant hemodynamic instability
Neonates with significant conjugated hyperbilirubinemia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effectiveness of Phototherapy <br/ ><br>-Rate of fall of Bilirubin <br/ ><br>-Duration of PhototherapyTimepoint: At baseline, then after every 12 hours till babies bilirubin values come down 2 mg/dl below the cutoff according to AAP chart for phototherapy.
- Secondary Outcome Measures
Name Time Method Parental Satisfaction <br/ ><br>Serum NO levels <br/ ><br>Serum calcium <br/ ><br>Vitamin D levels <br/ ><br>Temperature <br/ ><br>Skin rashes <br/ ><br>DNA breakage analysisTimepoint: At Baseline and at discharge i.e. when babies bilirubin values come down 2 mg/dl below the cutoff according to AAP chart for phototherapy.