The Effect of Consuming Enzymes and Prebiotics on Body Composition and Blood Biochemical Index
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 88
- 试验地点
- 2
- 主要终点
- The change of HDL-cholestrol
研究概览
简要总结
To assess the effects of consuming enzymes and prebiotics on improvement of weight loss and biochemical parameters
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female aged between 20 and 50 years old
- •Body mass index (BMI) ≥ 22 (kg/m^2) or body fat mass: male > 25%, female > 30%
- •Prohibitions on other nutritional supplements (probiotics and prebiotics) before two weeks of the study
- •Abidance by the similar diet and exercise habits over the study.
排除标准
- •Pregnant or breastfeeding woman
- •Menopausal woman
- •Diabetes mellitus
- •Implementation in weight loss programs before a half year of this study
- •Metabolic disorders
- •Kidney diseases
- •Liver diseases
- •Cardiovascular diseases
- •Nervous system diseases
- •Gastrointestinal diseases
- •Heavy drinking or constant drug use.
结局指标
主要结局
The change of HDL-cholestrol
时间窗: Months 0, 1 and 2
Venous blood was sampled to measure concentrations of HDL-cholestrol
The change of LDL-cholestrol
时间窗: Months 0, 1 and 2
Venous blood was sampled to measure concentrations of LDL-cholestrol
The change of visceral fat
时间窗: Months 0, 1 and 2
The visceral fat (10 cm\^2) was assessed by InBody770.
The change of body fat mass
时间窗: Months 0, 1 and 2
The body fat mass (kg) was assessed by InBody770.
The change of Triglyceride
时间窗: Months 0, 1 and 2
Venous blood was sampled to measure concentrations of Triglyceride
Fecal microbiome analysis
时间窗: Months 0, 1 and 2
Firmicutes, Bacteroidetes, Lactobucillius, and A. muciniphila were quantified by quantitative PCR.
The change of body fat percentage
时间窗: Months 0, 1 and 2
The body fat percentage (%) was assessed by InBody770.
The change of Total cholestrol
时间窗: Months 0, 1 and 2
Venous blood was sampled to measure concentrations of Total cholestrol
The change of body mass index (BMI)
时间窗: Months 0, 1 and 2
BMI is a measurement of a person's leanness or corpulence based on their height and weight, and is intended to quantify tissue mass.The body mass index (BMI, kg/m\^2) and body mass (kg) were assessed by InBody770.
次要结局
- The change of white blood cell(Months 0, 1 and 2)
- The change of uric acid(Months 0, 1 and 2)
- The change of alanine aminotransferase(Months 0, 1 and 2)
- The change of creatine(Months 0, 1 and 2)
- The change of fasting glycemia(Months 0, 1 and 2)
- The change of aspartate aminotransferase(Months 0, 1 and 2)
- The change of albumin(Months 0, 1 and 2)