NCT01519843SuspendedNot Applicable
Post-stroke Procedural Learning: From Neural Substrates to Therapeutic Modulation by Non-invasive Brain Stimulation
University Hospital of Mont-Godinne1 site in 1 country100 target enrollmentStarted: September 1, 2010Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Suspended
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Motor learning improvement with tDCS
Study Overview
Brief Summary
Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.
Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.
Detailed Description
transcranial direct current stimulation will be used for NIBS
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 95 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •stroke with at least slight deficit
Exclusion Criteria
- •contraindication to tDCS and/or to fMRI
- •presence of metal in the head
- •inability to understand / complete behavioral tasks
- •chronic intake of alcohol or recreational drugs
- •major health condition
- •presence of pacemaker (for the fMRI part only)
- •pregnancy
Outcomes
Primary Outcomes
Motor learning improvement with tDCS
Time Frame: Improvement on motor learning were recorded from baseline to 4 weeks after the intervention
performance on a motor skill learning task and on different commonly used task (Purdue Pegboard, hand dynamometer, pinch dynamometer, 9-HPT ,...) were measured to explore the impact of tDCS on these parameters
Secondary Outcomes
- Neuroimaging(before motor learning, during motor learning and after (immediately, 30,60min) motor learning (with or without tDCS))
- Neurophysiological outcome measure(start of session 5min before motor learning, just at the end of the motor learning, after 30 min of motor learning, after 60 min of motor learning, Recall test at 1,2,3,4 weeks after the day of intervention (with or without tDCS))
Investigators
Pr Yves Vandermeeren, MD, PhD
Professor
University Hospital of Mont-Godinne
Study Sites (1)
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