NCT01519843暂停不适用
Post-stroke Procedural Learning: From Neural Substrates to Therapeutic Modulation by Non-invasive Brain Stimulation
University Hospital of Mont-Godinne1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2010年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Motor learning improvement with tDCS
研究概览
简要总结
Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.
Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.
详细描述
transcranial direct current stimulation will be used for NIBS
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •stroke with at least slight deficit
排除标准
- •contraindication to tDCS and/or to fMRI
- •presence of metal in the head
- •inability to understand / complete behavioral tasks
- •chronic intake of alcohol or recreational drugs
- •major health condition
- •presence of pacemaker (for the fMRI part only)
- •pregnancy
结局指标
主要结局
Motor learning improvement with tDCS
时间窗: Improvement on motor learning were recorded from baseline to 4 weeks after the intervention
performance on a motor skill learning task and on different commonly used task (Purdue Pegboard, hand dynamometer, pinch dynamometer, 9-HPT ,...) were measured to explore the impact of tDCS on these parameters
次要结局
- Neuroimaging(before motor learning, during motor learning and after (immediately, 30,60min) motor learning (with or without tDCS))
- Neurophysiological outcome measure(start of session 5min before motor learning, just at the end of the motor learning, after 30 min of motor learning, after 60 min of motor learning, Recall test at 1,2,3,4 weeks after the day of intervention (with or without tDCS))
研究者
Pr Yves Vandermeeren, MD, PhD
Professor
University Hospital of Mont-Godinne
研究点 (1)
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