Post-stroke Procedural Learning: From Neural Substrates to Therapeutic Modulation by Non-invasive Brain Stimulation

University Hospital of Mont-Godinne1 site in 1 country100 target enrollmentSeptember 2010

ConditionsStroke Hemiparesis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Stroke
Sponsor: University Hospital of Mont-Godinne
Enrollment: 100
Locations: 1
Primary Endpoint: Motor learning improvement with tDCS
Status: Suspended
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.

Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.

Detailed Description

transcranial direct current stimulation will be used for NIBS

Registry

clinicaltrials.gov

Start Date

September 2010

End Date

December 2030

Last Updated

2 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

University Hospital of Mont-Godinne

Responsible Party

Principal Investigator

Pr Yves Vandermeeren, MD, PhD

Professor

University Hospital of Mont-Godinne

Eligibility Criteria

Inclusion Criteria

•stroke with at least slight deficit

Exclusion Criteria

•contraindication to tDCS and/or to fMRI
•presence of metal in the head
•inability to understand / complete behavioral tasks
•chronic intake of alcohol or recreational drugs
•major health condition
•presence of pacemaker (for the fMRI part only)
•pregnancy

Outcomes

Primary Outcomes

Motor learning improvement with tDCS

Time Frame: Improvement on motor learning were recorded from baseline to 4 weeks after the intervention

performance on a motor skill learning task and on different commonly used task (Purdue Pegboard, hand dynamometer, pinch dynamometer, 9-HPT ,...) were measured to explore the impact of tDCS on these parameters

Secondary Outcomes

Neuroimaging(before motor learning, during motor learning and after (immediately, 30,60min) motor learning (with or without tDCS))
Neurophysiological outcome measure(start of session 5min before motor learning, just at the end of the motor learning, after 30 min of motor learning, after 60 min of motor learning, Recall test at 1,2,3,4 weeks after the day of intervention (with or without tDCS))