Post Stroke Motor Learning

Not Applicable

Suspended

• Conditions: Hemiparesis; Stroke
• Interventions: Device: transcranial direct current stimulation tDCS; Device: transcranial magnetic stimulation TMS

• Registration Number: NCT01519843
• Lead Sponsor: University Hospital of Mont-Godinne

Brief Summary

Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.

Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.

Detailed Description

transcranial direct current stimulation will be used for NIBS

Study Timeline

• Study Start: 2010-09
• Study First Submitted: 2012-01-19
• Study First Submitted QC: 2012-01-24
• Study First Posted: 2012-01-27
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-08
• Last Update Posted: 2023-05-09
• Primary Completion: 2025-12
• Study Completion: 2030-12

Recruitment & Eligibility

• Status: SUSPENDED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• stroke with at least slight deficit

Exclusion Criteria

• epilepsy
• contraindication to tDCS and/or to fMRI
• presence of metal in the head
• inability to understand / complete behavioral tasks
• chronic intake of alcohol or recreational drugs
• major health condition
• presence of pacemaker (for the fMRI part only)
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
sham	transcranial direct current stimulation tDCS	Sham tDCS
Real	transcranial magnetic stimulation TMS	Real tDCS
Real	transcranial direct current stimulation tDCS	Real tDCS
sham	transcranial magnetic stimulation TMS	Sham tDCS

Primary Outcome Measures

Name	Time	Method
Motor learning improvement with tDCS	Improvement on motor learning were recorded from baseline to 4 weeks after the intervention	performance on a motor skill learning task and on different commonly used task (Purdue Pegboard, hand dynamometer, pinch dynamometer, 9-HPT ,...) were measured to explore the impact of tDCS on these parameters

Secondary Outcome Measures

Name	Time	Method
Neuroimaging	before motor learning, during motor learning and after (immediately, 30,60min) motor learning (with or without tDCS)	Does cerebral mechanisms underlying motor learning differ from healthy subject to stroke patients?
Neurophysiological outcome measure	start of session 5min before motor learning, just at the end of the motor learning, after 30 min of motor learning, after 60 min of motor learning, Recall test at 1,2,3,4 weeks after the day of intervention (with or without tDCS)	measure of brain excitability and connectivity with TMS (single and paired pulse)

Trial Locations

Locations (1)

Department of Neurology, CHU Mont-Godinne; 🇧🇪 Yvoir, Namur, Belgium