Effect of Ultraviolet Radiation on Blood Pressure, Cardiac Function and Insulin Sensitivity
Phase 3
Completed
- Conditions
- People with low vitamin D levelsCardiovascular - Normal development and function of the cardiovascular system
- Registration Number
- ACTRN12607000021471
- Lead Sponsor
- Health Research Council of New Zealand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Age - Pacific Island and Maori >50years, European >65years; 25OHD levels < 50 nmol/L.
Exclusion Criteria
Hypertension treated with thiazide diuretics, diabetes treated with insulin or oral hypoglycaemics, taking vitamin D supplements (including cod liver oil), planned travel to areas with high sun exposure during the study period.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood pressure[Measured at baseline and 12 weeks.]
- Secondary Outcome Measures
Name Time Method Insulin resistance (estimated from fasting insulin and triglycerides).[Baseline and 12 weeks];Cardiac function measured by Magnetic Resonance Imaging scan [At baseline and 12 weeks]
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms explain UVB-induced improvements in insulin resistance and blood pressure in vitamin D-deficient individuals?
How does UVB therapy compare to standard-of-care treatments for managing hypertension and insulin resistance in vitamin D-deficient patients?
Are there specific biomarkers that predict enhanced cardiac function following UVB exposure in phase III trials?
What adverse events are associated with UVB radiation in cardiovascular studies and how are they managed?
What combination therapies or alternative approaches are being explored alongside UVB for treating vitamin D deficiency-related cardiovascular issues?