Evaluation of Memantine’s Effect on Symptom Characteristics in Patients with Obsessive Compulsive Disorder
- Conditions
- Obsessive Compulsive Disorder (OCD).Obsessive-compulsive disorder
- Registration Number
- IRCT20140120016280N4
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 48
Definitive diagnosis of obsessive-compulsive disorder based on the psychiatrist assessment and its confirmation according to SCID-5 (Structured-Clinical Interview for DSM5) by the clinical psychologist
Y-BOCS Score equal or more than 16 for obsessions and compulsions or equal or more than 10 only for obsessions or compulsions.
Being in The age range of 18-50
IQ level more than 80 based on Wechsler Adult Intelligence Scale
Signing written informed consent
Subjects with major depressive disorder, bipolar disorder, personality disorder, and schizophrenia in a way that questions the diagnose of obsessive-compulsive disorder.
Pregnancy, lactation or the imminent possibility of either of these cases or use of birth control methods for female subjects (these items will be assessed by the validated urine tests)
Past or current drug/alcohol abuse or dependence (these items will be assessed by the urine toxicology tests)
Previous exposure to any kind of psychotropic medication (benzodiazepines, antipsychotics, antidepressants, stimulants, mood stabilizers)
Previous exposure to at least 8 sessions of structured psycho-therapeutic courses
Past history or current existence of neurological diseases (seizures, epilepsy syndromes, history of trauma, stroke, loss of consciousness) and other severe internal and surgical disorders
Presence of any contraindication to MRI scanning, including metal implants or claustrophobia. Metal implants, pacemaker, other metal (e.g. shrapnel or surgical prostheses) or paramagnetic objects contained within the body which may present a risk to the subject or interfere with the MR scan, as determined in consultation with a neuroradiologist and according to the guidelines set forth in the following reference book commonly used by the neuroradiologists:Guide to MR procedures and metallic objects, F. G.
Increase in liver enzymes SGOT and SGPT more than threefold compared with baseline levels.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method