Study of neuroinflammation and aging of Alzheimer's dementia using multimodal neuroimaging (MRI and PET)

Gachon University Gil Medical Center0 个研究点目标入组 360 人开始时间: 待定最近更新: 2020年10月5日

试验速览

暂无简介。

•Cognitively Normal (CN) • Normal cognition will be defined
•according to neuropsychological testing, which didn't fall within 1.5 SD,
•and Clinical Dementia Rating (CDR) was 0 . - Mild cognitive impairment (MCI):
•CDR was 0.5 • Subjects were not be clinically diagnosed with dementia
•according to Diagnostic and Statistical Manual of Mental Disorders, 4th.
•Edition, Text-revision (DSM-IV-TR) criteria. - Dementia (AD) - Alzheimer's
•disease (AD): • CDR = 0.5 • subjects were diagnosed with dementia according to
•DSM-IV-TR. • subjects were diagnosed with probable AD or possible AD according
•to the National Institute of Neurological and Communicative Disorders and Stroke
•and the Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA)

•- Subjects who do not meet the inclusion criteria. -
•Subjects who have history of any significant neurological disease other than AD
•or VD , such as traumatic brain injury, Parkinson's disease,
•Huntington's disease, motor neuron disease, or multiple sclerosis. -
•Subjects who have history of brain tumor, normal presure hydrocephalus,
•encephalitis, or metabolic encephalopathy. - Subjects who have history of a
•massive stroke in cerebrum, brain strem or cerebellum. - Subjects who have
•history of psychiatric disorder. - Subjects unable to undergo MRI or PET
•scanning. - Pregnent or reast feeding women.

发起方