Comparison of the work-of-breathing and the activity of the muscles of breathing through Surface-electromyography during invasive lung Ventilatio

• Conditions: J44; J84; Other chronic obstructive pulmonary disease; Other interstitial pulmonary diseases

• Registration Number: DRKS00015780
• Lead Sponsor: Drägerwerk AG & Co.KGaA

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-23
• Study Completion: 2020-03-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Indication for elective bronchoscopy:
- COPD GOLD II-III (chronic obstructive pulmonary disease)
- Interstitial lung disease (confirmed or suspected)
- Age > 18 years

Exclusion Criteria

- indication for acute bronchoscopy (i.e. hemoptysis, tumor-recanalisation)
- neuromuscular diseases
- drug abuse
- anamnestic esphageal Stenosis or varices
- risk for bleeding in the laborchemistry
- pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Primary Goal is to identify changes in the work of brathing and the sEMG-signal (Surface-electromyography) during invasive ventilatkion.<br>For aquiring these information we continously monitor the sEMG of the diaphragm and the intercostal muscles via small electrodes glued to the Skin as well as the esophageal pressure via a esophageal probe.<br>During assisted Ventilation the data provided by the lung Ventilator (mouth pressure, gas-flow, FiO2, FeCO2) were also documented.

Secondary Outcome Measures

Name	Time	Method
Another Point of interest were the changes in the sEMG-signal provoked by movements (cough, active and passive movements of the extremities).