Clinical and Biochemical Effects of Multipass Hemodialysis

Phase 2

Completed

• Conditions: Uremia
• Interventions: Device: Multipass hemodialysis

• Registration Number: NCT01267760
• Lead Sponsor: Herlev Hospital

Brief Summary

The purpose of this study is to investigate whether recycled dialysis fluid can supply enough clearance for hemodiaysis patients.

Detailed Description

Conventional hemodialysis uses large amounts of water, which hinders travel possibilies for home hemodialysis (HD) patients. We have developed a recycling system using 25-30 l dialysate per dialysis. In vitro investigations show that this results in adequate dialysis.

12 HD patients will be studied during two dialysis sessions. The first HD will be a conventional 4 hour dialysis, using single pass dialysate. The second will be an 8-hour HD using multipass (recycled) dialysate 25-30 l. Clearance of urea, creatinine, phosphate and cobalamin will be measured both in the patient and the dialysate. Patient symptoms will be recorded.

Study Timeline

• Study First Submitted: 2010-01-26
• Study First Submitted QC: 2010-12-27
• Study First Posted: 2010-12-28
• Study Start: 2011-03
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-06
• Last Update Posted: 2013-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Stable chronic HD patients
• Informed consent

Exclusion Criteria

• Age <18 years
• Psychiatric disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
conventional HD	Multipass hemodialysis	conventional 4-hour HD

Primary Outcome Measures

Name	Time	Method
Urea Kt/V	9 hours

Secondary Outcome Measures

Name	Time	Method
Creatinine clearance	9 hours
Patient symptoms	9 hours

Trial Locations

Locations (1)

Herlev Hospital; 🇩🇰 Herlev, Denmark