ISRCTN26221020已完成未知
A randomized phase IV clinical trial comparing Nadolol and Isosorbide Mononitrate (ISMN) with the combination of Endoscopic Banding Ligation plus Nadolol and ISMN in the prevention of variceal rebleeding
Individual Sponsor (Spain)0 个研究点目标入组 160 人开始时间: 2006年3月24日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 160
研究概览
简要总结
2009 Results article in http://www.ncbi.nlm.nih.gov/pubmed/19218249 pub
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Age between 18-75
- •2. Diagnosis of cirrhosis
- •3. Hematemesis or melena within 7 days prior to inclusion
- •4. Esophageal or gastroesophageal varices as the source of bleeding
- •5. Written informed consent
- •6. Exclusion of pregnancy in woman of child-bearing potential
排除标准
- •1. Hepatocellular carcinoma >5 cm or multinodular
- •2.Creatinine >2 mg/dl
- •3. Child-Pugh =13 points
- •4. Contraindications to beta-adrenergic blockers
- •5. Contraindications to ISMN
- •6. Banding ligation in the 3 months before the present episode of variceal bleeding
- •7. Previous portosystemic derivative therapy
- •8. Bleeding from fundal or ectopic varices
- •9. Total portal vein thrombosis or portal vein cavernomatosis
- •10. The patient was already on beta-adrenergic blockers and ISMN for the prevention of variceal bleeding
研究者
相似试验
已完成
3 期
Is Hedrin® 4% lotion Dev 42 more effective than Hedrin® 4% lotion against head louse eggs?Head louse infestationInfections and InfestationsPediculosis and phthiriasisISRCTN10431107Thornton & Ross Ltd (UK)72
已完成
3 期
A randomised phase III clinical trial investigating the effect of Fragmin® added to standard therapy In patients with lung cancerCancerISRCTN80812769Velindre NHS Trust (UK)2,202
已完成
不适用
A randomised, multicentre, open label trial comparing the start of the induction of labour with intravenous oxytocin according to the circadian rhythm with standard careInduction of labour with intravenous oxytocinPregnancy and ChildbirthLabour inductionISRCTN52897947Academic Medical Centre (AMC) (Netherlands)371
已完成
不适用
A randomised controlled trial to compare normoxic versus standard cardiopulmonary bypass in cyanotic children undergoing cardiac surgeryISRCTN81773762niversity Hospitals Bristol NHS Foundation Trust90
已完成
不适用
Intra-articular Hyalubrix® injections versus local anaesthetic in hip osteoarthritisMusculoskeletal DiseasesCoxarthrosisHip osteoarthritisISRCTN39397064Fidia Farmaceutici S.p.A. (Italy)42