Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide)
- Conditions
- Acute Coronary Syndrome
- Interventions
- Drug: Placebo
- Registration Number
- NCT01147250
- Lead Sponsor
- Sanofi
- Brief Summary
Primary Objective:
- To demonstrate that lixisenatide can reduce cardiovascular (CV) morbidity and mortality (composite endpoint of CV death, non-fatal myocardial infarction (MI), non-fatal stroke, hospitalization for unstable angina) compared to placebo in type 2 diabetic participants who recently experienced an acute coronary syndrome (ACS) event.
Secondary Objectives:
To demonstrate that when compared to placebo, lixisenatide can reduce:
* composite endpoint of CV death, non-fatal MI, non-fatal stroke, hospitalization for unstable angina, or hospitalization for heart failure.
* composite endpoint of CV death, non-fatal MI, non-fatal stroke, hospitalization for unstable angina, hospitalization for heart failure, or coronary revascularization procedure.
* urinary albumin excretion (based on the urinary albumin/creatinine ratio).
To assess the safety and tolerability of lixisenatide.
- Detailed Description
The estimated maximum study duration for the first randomized participant was approximately 204 weeks (± 14 days), with a median follow-up over all participants of approximately 91 weeks, broken down as follows:
* placebo-run-in period: 7 days (+ 3 days)
* double-blind study treatment period: 203 weeks (± 14 days) (with about a 37 months of recruitment period)
* post-treatment follow-up period: 3 days (± 1 day)
All participants were followed from randomization until the end of study, which should occur when the last randomized participant had been followed for approximately 10 months. The actual end date of the study was "event driven" and the study end when there were approximately 844 positively-adjudicated primary cardiovascular outcome events.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6068
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Placebo matched to lixisenatide once daily (QD) up to end of treatment. Lixisenatide Lixisenatide (AVE0010) Lixisenatide 10 mcg QD for 2 weeks post-randomization, then at a maintenance dose of 20 mcg QD up to end of treatment.
- Primary Outcome Measures
Name Time Method Time to First Occurence of Primary CV Event: CV Death, Non-Fatal MI, Non-Fatal Stroke or Hospitalization for Unstable Angina From randomization up to the end of study (median follow-up of 25 months) Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the onset of primary CV endpoint over time. Number of observed participants with endpoint events were reported. A CV event adjudication committee (CAC) reviewed and adjudicated, in a blinded fashion, all potential events.
- Secondary Outcome Measures
Name Time Method Time to First Occurence of CV Event: CV Death, Non-Fatal MI, Non-Fatal Stroke, Hospitalization for Unstable Angina, Hospitalization For Heart Failure or Coronary Revascularization Procedure From randomization up to the end of study (median follow-up of 25 months) All CV events were positively adjudicated by CAC, used in the analysis of the composite CV endpoint comprised of CV death, non-fatal MI, non-fatal stroke, hospitalization for unstable angina, hospitalization for heart failure, or coronary revascularization procedure. Number of observed participants with endpoint events were reported.
Percent Change From Baseline in the Urinary Albumin/Creatinine Ratio (UACR) at Week 108 Baseline to Week 108 (LOCF) Presence of albumin in urine is a marker of nephropathy, an important microvascular complication of diabetes. UACR was defined as the ratio: mg of albumin per gram of creatinine. UACR data were log transformed before the analysis. Calculation was based on geometric mean.
Time to First Occurence of CV Event: CV Death, Non-Fatal MI, Non-Fatal Stroke, Hospitalization for Unstable Angina or Hospitalization For Heart Failure From randomization up to the end of study (median follow-up of 25 months) All CV events were positively adjudicated by the CAC, used in the analysis of the composite CV endpoint comprised of CV death, non-fatal MI, non-fatal stroke, hospitalization for unstable angina or hospitalization for heart failure. Number of observed participants with endpoint events were reported.
Trial Locations
- Locations (829)
Investigational Site Number 428003
🇱🇻Riga, Latvia
Investigational Site Number 428007
🇱🇻Riga, Latvia
Investigational Site Number 428004
🇱🇻Riga, Latvia
Investigational Site Number 484016
🇲🇽Chihuahua, Mexico
Investigational Site Number 484013
🇲🇽Mexico City, Mexico
Investigational Site Number 484003
🇲🇽Monterrey, Mexico
Investigational Site Number 484025
🇲🇽Monterrey, Mexico
Investigational Site Number 484002
🇲🇽Monterrey, Mexico
Investigational Site Number 392027
🇯🇵Hakusan-Shi, Japan
Investigational Site Number 392002
🇯🇵Noda-Shi, Japan
Investigational Site Number 392010
🇯🇵Sapporo-Shi, Japan
Investigational Site Number 392004
🇯🇵Shinagawa-Ku, Japan
Investigational Site Number 440004
🇱🇹Klaipeda, Lithuania
Investigational Site Number 392021
🇯🇵Osaka-Shi, Japan
Investigational Site Number 392001
🇯🇵Sapporo-Shi, Japan
Investigational Site Number 392024
🇯🇵Setagaya-Ku, Japan
Investigational Site Number 440006
🇱🇹Klaipeda, Lithuania
Investigational Site Number 392023
🇯🇵Takasaki-Shi, Japan
Investigational Site Number 392014
🇯🇵Shirakawa-Shi, Japan
Investigational Site Number 392018
🇯🇵Suita-Shi, Japan
Investigational Site Number 392016
🇯🇵Tachikawa-Shi, Japan
Investigational Site Number 608001
🇵🇭Manila, Philippines
Investigational Site Number 428006
🇱🇻Sigulda, Latvia
Investigational Site Number 440003
🇱🇹Kaunas, Lithuania
Investigational Site Number 484007
🇲🇽Durango, Mexico
Investigational Site Number 484001
🇲🇽Durango, Mexico
Investigational Site Number 484032
🇲🇽Guadalajara, Mexico
Investigational Site Number 484034
🇲🇽Guadalajara, Mexico
Investigational Site Number 484021
🇲🇽Guadalajara, Mexico
Investigational Site Number 484006
🇲🇽Guadalajara, Mexico
Investigational Site Number 484018
🇲🇽Guadalajara, Mexico
Investigational Site Number 484024
🇲🇽Leon, Mexico
Investigational Site Number 484026
🇲🇽Mexico City, Mexico
Investigational Site Number 484022
🇲🇽Mexico City, Mexico
Investigational Site Number 484005
🇲🇽Monterrey, Mexico
Investigational Site Number 484004
🇲🇽Monterrey, Mexico
Investigational Site Number 484035
🇲🇽Morelia, Mexico
Investigational Site Number 528005
🇳🇱Alkmaar, Netherlands
Investigational Site Number 528007
🇳🇱Den Haag, Netherlands
Investigational Site Number 484020
🇲🇽San Luis Potosi, Mexico
Investigational Site Number 484017
🇲🇽Tlalnepantla, Mexico
Investigational Site Number 484031
🇲🇽Xalapa, Mexico
Investigational Site Number 528008
🇳🇱Deventer, Netherlands
Investigational Site Number 528001
🇳🇱Rotterdam, Netherlands
Investigational Site Number 528004
🇳🇱Hoorn, Netherlands
Investigational Site Number 528003
🇳🇱Tilburg, Netherlands
Investigational Site Number 528006
🇳🇱Venlo, Netherlands
Investigational Site Number 578003
🇳🇴Bodø, Norway
Investigational Site Number 591004
🇵🇦La Chorrera, Panama
Investigational Site Number 604002
🇵🇪Lima, Peru
Investigational Site Number 604018
🇵🇪Lima, Peru
Investigational Site Number 604001
🇵🇪Lima, Peru
Investigational Site Number 608003
🇵🇭Makati City, Philippines
Investigational Site Number 591002
🇵🇦Penonome, Panama
Investigational Site Number 604007
🇵🇪Arequipa, Peru
Investigational Site Number 604014
🇵🇪Callao, Peru
Investigational Site Number 604011
🇵🇪Lima, Peru
Investigational Site Number 604019
🇵🇪Lima, Peru
Investigational Site Number 604013
🇵🇪Lima, Peru
Investigational Site Number 604006
🇵🇪Lima, Peru
Investigational Site Number 604010
🇵🇪Lima, Peru
Investigational Site Number 604015
🇵🇪Lima, Peru
Investigational Site Number 616025
🇵🇱Szczecin, Poland
Investigational Site Number 604005
🇵🇪Lima, Peru
Investigational Site Number 604009
🇵🇪Lima, Peru
Investigational Site Number 608009
🇵🇭Iligan City, Lanao Del Norte, Philippines
Investigational Site Number 608006
🇵🇭Cavite, Philippines
Investigational Site Number 616024
🇵🇱Krakow, Poland
Investigational Site Number 616006
🇵🇱Ruda Slaska, Poland
Investigational Site Number 616032
🇵🇱Warszawa, Poland
Investigational Site Number 616020
🇵🇱Wroclaw, Poland
Investigational Site Number 616011
🇵🇱Wroclaw, Poland
Investigational Site Number 608007
🇵🇭Manila, Philippines
Investigational Site Number 608002
🇵🇭Pasay City, Philippines
Investigational Site Number 616012
🇵🇱Czeladz, Poland
Investigational Site Number 616023
🇵🇱Poland, Poland
Investigational Site Number 608008
🇵🇭Quezon City, Philippines
Investigational Site Number 616028
🇵🇱Grodzisk Mazowiecki, Poland
Investigational Site Number 616022
🇵🇱Katowice, Poland
Investigational Site Number 616014
🇵🇱Gdynia, Poland
Investigational Site Number 616007
🇵🇱Czestochowa, Poland
Investigational Site Number 616013
🇵🇱Gliwice, Poland
Investigational Site Number 616001
🇵🇱Krakow, Poland
Investigational Site Number 616021
🇵🇱Pulawy, Poland
Investigational Site Number 616031
🇵🇱Zgierz, Poland
Investigational Site Number 620005
🇵🇹Amadora, Portugal
Investigational Site Number 620003
🇵🇹Coimbra, Portugal
Investigational Site Number 620001
🇵🇹Lisboa, Portugal
Investigational Site Number 642020
🇷🇴Baia Mare, Romania
Investigational Site Number 620007
🇵🇹Penafiel, Portugal
Investigational Site Number 620006
🇵🇹Porto, Portugal
Investigational Site Number 642029
🇷🇴Arad, Romania
Investigational Site Number 642019
🇷🇴Braila, Romania
Investigational Site Number 642003
🇷🇴Brasov, Romania
Investigational Site Number 642034
🇷🇴Bucharest, Romania
Investigational Site Number 642022
🇷🇴Bucuresti, Romania
Investigational Site Number 642001
🇷🇴Bucuresti, Romania
Investigational Site Number 642013
🇷🇴Bucuresti, Romania
Investigational Site Number 642010
🇷🇴Iasi, Romania
Investigational Site Number 642016
🇷🇴Oradea, Romania
Investigational Site Number 642002
🇷🇴Ploiesti, Romania
Investigational Site Number 642009
🇷🇴Suceava, Romania
Investigational Site Number 642012
🇷🇴Targu Mures, Romania
Investigational Site Number 642018
🇷🇴Timisoara, Romania
Investigational Site Number 642031
🇷🇴Timisoara, Romania
Investigational Site Number 643023
🇷🇺Barnaul, Russian Federation
Investigational Site Number 643044
🇷🇺Kazan, Russian Federation
Investigational Site Number 643006
🇷🇺Kemerovo, Russian Federation
Investigational Site Number 643005
🇷🇺Kemerovo, Russian Federation
Investigational Site Number 643061
🇷🇺Krasnodar, Russian Federation
Investigational Site Number 643027
🇷🇺Krasnodar, Russian Federation
Investigational Site Number 643037
🇷🇺Moscow, Russian Federation
Investigational Site Number 643038
🇷🇺Moscow, Russian Federation
Investigational Site Number 643043
🇷🇺Moscow, Russian Federation
Investigational Site Number 643002
🇷🇺Moscow, Russian Federation
Investigational Site Number 643008
🇷🇺Moscow, Russian Federation
Investigational Site Number 643009
🇷🇺Moscow, Russian Federation
Investigational Site Number 643029
🇷🇺Moscow, Russian Federation
Investigational Site Number 643018
🇷🇺Moscow, Russian Federation
Investigational Site Number 643026
🇷🇺Moscow, Russian Federation
Investigational Site Number 643003
🇷🇺Moscow, Russian Federation
Investigational Site Number 643042
🇷🇺Moscow, Russian Federation
Investigational Site Number 643052
🇷🇺Moscow, Russian Federation
Investigational Site Number 643051
🇷🇺Moscow, Russian Federation
Investigational Site Number 643013
🇷🇺Moscow, Russian Federation
Investigational Site Number 643001
🇷🇺Moscow, Russian Federation
Investigational Site Number 643034
🇷🇺Nizhny Novgorod, Russian Federation
Investigational Site Number 643054
🇷🇺Novosibirsk, Russian Federation
Investigational Site Number 643055
🇷🇺Novosibirsk, Russian Federation
Investigational Site Number 643047
🇷🇺Ryazan, Russian Federation
Investigational Site Number 643040
🇷🇺Moscow, Russian Federation
Investigational Site Number 643045
🇷🇺Omsk, Russian Federation
Investigational Site Number 643030
🇷🇺Penza, Russian Federation
Investigational Site Number 643017
🇷🇺Perm, Russian Federation
Investigational Site Number 643049
🇷🇺Perm, Russian Federation
Investigational Site Number 643035
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643048
🇷🇺Rostov-Na-Donu, Russian Federation
Investigational Site Number 643039
🇷🇺Saint-Petersburg, Russian Federation
Investigational Site Number 643022
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643025
🇷🇺Saratov, Russian Federation
Investigational Site Number 643057
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643011
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643004
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 688002
🇷🇸Belgrade, Serbia
Investigational Site Number 688008
🇷🇸Belgrade, Serbia
Investigational Site Number 688009
🇷🇸Belgrade, Serbia
Investigational Site Number 688001
🇷🇸Belgrade, Serbia
Investigational Site Number 643058
🇷🇺Voronezh, Russian Federation
Investigational Site Number 643020
🇷🇺Yaroslavl, Russian Federation
Investigational Site Number 688003
🇷🇸Belgrade, Serbia
Investigational Site Number 688005
🇷🇸Nis, Serbia
Investigational Site Number 233006
🇪🇪Viljandimaa, Estonia
Investigational Site Number 756003
🇨🇭Lugano, Switzerland
Investigational Site Number 158006
🇨🇳Tainan Hsien, Taiwan
Investigational Site Number 158007
🇨🇳Taipei 111, Taiwan
Investigational Site Number 158004
🇨🇳Taichung, Taiwan
Investigational Site Number 158003
🇨🇳Taipei Hsien, Taiwan
Investigational Site Number 788002
🇹🇳Tunis, Tunisia
Investigational Site Number 788001
🇹🇳Tunis, Tunisia
Investigational Site Number 804010
🇺🇦Kharkiv, Ukraine
Investigational Site Number 158001
🇨🇳Taipei, Taiwan
Investigational Site Number 158008
🇨🇳Taipei, Taiwan
Investigational Site Number 788003
🇹🇳Sfax, Tunisia
Investigational Site Number 804006
🇺🇦Dnepropetrovsk, Ukraine
Investigational Site Number 788005
🇹🇳Tunis, Tunisia
Investigational Site Number 788004
🇹🇳Tunis, Tunisia
Investigational Site Number 804003
🇺🇦Kiev, Ukraine
Investigational Site Number 804013
🇺🇦Kyiv, Ukraine
Investigational Site Number 804005
🇺🇦Lviv, Ukraine
Investigational Site Number 804004
🇺🇦Chernivtsi, Ukraine
Investigational Site Number 804002
🇺🇦Dnipropetrovsk, Ukraine
Investigational Site Number 804009
🇺🇦Kharkov, Ukraine
Investigational Site Number 804012
🇺🇦Kyiv, Ukraine
Investigational Site Number 804008
🇺🇦Odessa, Ukraine
Investigational Site Number 804007
🇺🇦Odessa, Ukraine
Investigational Site Number 784001
🇦🇪Abu Dhabi, United Arab Emirates
Investigational Site Number 784002
🇦🇪Dubai, United Arab Emirates
Investigational Site Number 840168
🇺🇸Owensboro, Kentucky, United States
Investigational Site Number 840178
🇺🇸Shreveport, Louisiana, United States
Investigational Site Number 840131
🇺🇸Santa Ana, California, United States
Investigational Site Number 840042
🇺🇸Tucson, Arizona, United States
Investigational Site Number 840293
🇺🇸Towson, Maryland, United States
Investigational Site Number 840536
🇺🇸Idaho Falls, Idaho, United States
Investigational Site Number 840413
🇺🇸Pocatello, Idaho, United States
Investigational Site Number 840430
🇺🇸Rockville, Maryland, United States
Investigational Site Number 840072
🇺🇸Linden, New Jersey, United States
Investigational Site Number 840628
🇺🇸Ridgewood, New Jersey, United States
Investigational Site Number 840162
🇺🇸Somerset, New Jersey, United States
Investigational Site Number 840353
🇺🇸Columbia, South Carolina, United States
Investigational Site Number 840524
🇺🇸Bartlett, Tennessee, United States
Investigational Site Number 840550
🇺🇸Greer, South Carolina, United States
Investigational Site Number 840529
🇺🇸Green Ville, South Carolina, United States
Investigational Site Number 840258
🇺🇸Myrtle Beach, South Carolina, United States
Investigational Site Number 840309
🇺🇸Taylors, South Carolina, United States
Investigational Site Number 840625
🇺🇸Memphis, Tennessee, United States
Investigational Site Number 840551
🇺🇸Rapid City, South Dakota, United States
Investigational Site Number 840047
🇺🇸Germantown, Tennessee, United States
Investigational Site Number 840308
🇺🇸Chattanooga, Tennessee, United States
Investigational Site Number 840313
🇺🇸Jackson, Tennessee, United States
Investigational Site Number 840637
🇺🇸Memphis, Tennessee, United States
Investigational Site Number 032056
🇦🇷Caba, Argentina
Investigational Site Number 032003
🇦🇷Caba, Argentina
Investigational Site Number 032017
🇦🇷Capital Federal, Argentina
Investigational Site Number 032037
🇦🇷Cordoba, Argentina
Investigational Site Number 032020
🇦🇷Coronel Suarez, Argentina
Investigational Site Number 032004
🇦🇷Corrientes, Argentina
Investigational Site Number 032009
🇦🇷Capital Federal, Argentina
Investigational Site Number 032050
🇦🇷Cipolletti, Argentina
Investigational Site Number 032005
🇦🇷Godoy Cruz, Argentina
Investigational Site Number 032042
🇦🇷Haedo, Argentina
Investigational Site Number 032063
🇦🇷La Plata, Argentina
Investigational Site Number 032036
🇦🇷Mar Del Plata, Argentina
Investigational Site Number 032015
🇦🇷Córdoba, Argentina
Investigational Site Number 032039
🇦🇷Mar Del Plata, Argentina
Investigational Site Number 032058
🇦🇷Mendoza, Argentina
Investigational Site Number 032038
🇦🇷Moron, Argentina
Investigational Site Number 032047
🇦🇷Rafaela, Argentina
Investigational Site Number 032006
🇦🇷Resistencia, Argentina
Investigational Site Number 032012
🇦🇷Rosario, Argentina
Investigational Site Number 032027
🇦🇷Rosario, Argentina
Investigational Site Number 032055
🇦🇷Salta, Argentina
Investigational Site Number 032065
🇦🇷Salta, Argentina
Investigational Site Number 032051
🇦🇷San Miguel De Tucuman, Argentina
Investigational Site Number 032008
🇦🇷San Miguel De Tucuman, Argentina
Investigational Site Number 032035
🇦🇷Santa Fe, Argentina
Investigational Site Number 032062
🇦🇷Santa Rosa, Argentina
Investigational Site Number 032034
🇦🇷Venado Tuerto, Argentina
Investigational Site Number 032046
🇦🇷Villa Maria, Argentina
Investigational Site Number 032029
🇦🇷Zarate, Argentina
Investigational Site Number 040002
🇦🇹Graz, Austria
Investigational Site Number 040001
🇦🇹Wien, Austria
Investigational Site Number 112002
🇧🇾Minsk, Belarus
Investigational Site Number 112003
🇧🇾Minsk, Belarus
Investigational Site Number 112001
🇧🇾Minsk, Belarus
Investigational Site Number 056001
🇧🇪Bruxelles, Belgium
Investigational Site Number 056003
🇧🇪Leuven, Belgium
Investigational Site Number 100011
🇧🇬Gabrovo, Bulgaria
Investigational Site Number 100001
🇧🇬Kazanluk, Bulgaria
Investigational Site Number 100015
🇧🇬Sofia, Bulgaria
Investigational Site Number 100007
🇧🇬Plovdiv, Bulgaria
Investigational Site Number 100010
🇧🇬Sofia, Bulgaria
Investigational Site Number 100016
🇧🇬Sandanski, Bulgaria
Investigational Site Number 152040
🇨🇱Puerto Montt, Chile
Investigational Site Number 152038
🇨🇱Punta Arenas, Chile
Investigational Site Number 152036
🇨🇱San Felipe, Chile
Investigational Site Number 100005
🇧🇬Varna, Bulgaria
Investigational Site Number 152024
🇨🇱Antofagasta, Chile
Investigational Site Number 152041
🇨🇱Osorno, Chile
Investigational Site Number 152023
🇨🇱Concepcion, Chile
Investigational Site Number 152008
🇨🇱Santiago, Chile
Investigational Site Number 152003
🇨🇱Temuco, Chile
Investigational Site Number 152035
🇨🇱Santiago, Chile
Investigational Site Number 152020
🇨🇱Santiago, Chile
Investigational Site Number 152028
🇨🇱Santiago, Chile
Investigational Site Number 152031
🇨🇱Santiago, Chile
Investigational Site Number 152001
🇨🇱Santiago, Chile
Investigational Site Number 152034
🇨🇱Santiago, Chile
Investigational Site Number 152015
🇨🇱Santiago, Chile
Investigational Site Number 152004
🇨🇱Santiago, Chile
Investigational Site Number 152010
🇨🇱Viña Del Mar, Chile
Investigational Site Number 152013
🇨🇱Santiago, Chile
Investigational Site Number 152019
🇨🇱Santiago, Chile
Investigational Site Number 152018
🇨🇱Santiago, Chile
Investigational Site Number 152042
🇨🇱Santiago, Chile
Investigational Site Number 152029
🇨🇱Santiago, Chile
Investigational Site Number 152022
🇨🇱Santiago, Chile
Investigational Site Number 152011
🇨🇱Santiago, Chile
Investigational Site Number 152025
🇨🇱Talca, Chile
Investigational Site Number 152014
🇨🇱Temuco, Chile
Investigational Site Number 152037
🇨🇱Valdivia, Chile
Investigational Site Number 152032
🇨🇱Valparaíso, Chile
Investigational Site Number 152002
🇨🇱Vina Del Mar, Chile
Investigational Site Number 170009
🇨🇴Barranquilla, Colombia
Investigational Site Number 170012
🇨🇴Bogota, Colombia
Investigational Site Number 170010
🇨🇴Barranquilla, Colombia
Investigational Site Number 170002
🇨🇴Bogota, Colombia
Investigational Site Number 170014
🇨🇴Bogota, Colombia
Investigational Site Number 170022
🇨🇴Bogota, Colombia
Investigational Site Number 170004
🇨🇴Bucaramanga, Colombia
Investigational Site Number 170005
🇨🇴Bogota, Colombia
Investigational Site Number 170026
🇨🇴Espinal - Tolima, Colombia
Investigational Site Number 170007
🇨🇴Floridablanca, Colombia
Investigational Site Number 170017
🇨🇴Cali, Colombia
Investigational Site Number 170024
🇨🇴Cali, Colombia
Investigational Site Number 170013
🇨🇴Cartagena, Colombia
Investigational Site Number 170008
🇨🇴Floridablanca, Colombia
Investigational Site Number 170019
🇨🇴Manizales, Colombia
Investigational Site Number 170003
🇨🇴Medellin, Colombia
Investigational Site Number 170020
🇨🇴Medellin, Colombia
Investigational Site Number 170021
🇨🇴Pereira, Colombia
Investigational Site Number 218001
🇪🇨Guayaquil, Ecuador
Investigational Site Number 246005
🇫🇮Jyväskylä, Finland
Investigational Site Number 218005
🇪🇨Guayaquil, Ecuador
Investigational Site Number 218002
🇪🇨Quito, Ecuador
Investigational Site Number 818001
🇪🇬Cairo, Egypt
Investigational Site Number 818002
🇪🇬Alexandria, Egypt
Investigational Site Number 233001
🇪🇪Tallinn, Estonia
Investigational Site Number 233003
🇪🇪Tallinn, Estonia
Investigational Site Number 233005
🇪🇪Tartu, Estonia
Investigational Site Number 233004
🇪🇪Tallinn, Estonia
Investigational Site Number 246003
🇫🇮Rauma, Finland
Investigational Site Number 246009
🇫🇮Turku, Finland
Investigational Site Number 246007
🇫🇮Valkeakoski, Finland
Investigational Site Number 246012
🇫🇮Vantaa, Finland
Investigational Site Number 268001
🇬🇪Tbilisi, Georgia
Investigational Site Number 268002
🇬🇪Tbilisi, Georgia
Investigational Site Number 320006
🇬🇹Guatemala, Guatemala
Investigational Site Number 320014
🇬🇹Guatemala, Guatemala
Investigational Site Number 320001
🇬🇹Guatemala, Guatemala
Investigational Site Number 320002
🇬🇹Guatemala, Guatemala
Investigational Site Number 320012
🇬🇹Guatemala, Guatemala
Investigational Site Number 320008
🇬🇹Guatemala, Guatemala
Investigational Site Number 356012
🇮🇳Chandigarh, India
Investigational Site Number 320007
🇬🇹Guatemala, Guatemala
Investigational Site Number 320015
🇬🇹Quetzaltenango, Guatemala
Investigational Site Number 356019
🇮🇳Ahmedabad, India
Investigational Site Number 356026
🇮🇳Bangalore, India
Investigational Site Number 356020
🇮🇳Hyderabad, India
Investigational Site Number 356027
🇮🇳Nagpur, India
Investigational Site Number 376001
🇮🇱Holon, Israel
Investigational Site Number 376011
🇮🇱Nahariya, Israel
Investigational Site Number 376003
🇮🇱Tel Hashomer, Israel
Investigational Site Number 840446
🇺🇸Atlanta, Georgia, United States
Investigational Site Number 840487
🇺🇸Atlanta, Georgia, United States
Investigational Site Number 840261
🇺🇸Miami, Florida, United States
Investigational Site Number 156034
🇨🇳Beijing, China
Investigational Site Number 156024
🇨🇳Beijing, China
Investigational Site Number 156005
🇨🇳Beijing, China
Investigational Site Number 156006
🇨🇳Beijing, China
Investigational Site Number 156008
🇨🇳Dalian, China
Investigational Site Number 156020
🇨🇳Guangzhou, China
Investigational Site Number 156001
🇨🇳Beijing, China
Investigational Site Number 840307
🇺🇸Foley, Alabama, United States
Investigational Site Number 840692
🇺🇸Mobile, Alabama, United States
Investigational Site Number 840037
🇺🇸Mobile, Alabama, United States
Investigational Site Number 840210
🇺🇸Mobile, Alabama, United States
Investigational Site Number 840326
🇺🇸Muscle Shoals, Alabama, United States
Investigational Site Number 840656
🇺🇸Mesa, Arizona, United States
Investigational Site Number 840706
🇺🇸Anaheim, California, United States
Investigational Site Number 840667
🇺🇸Downey, California, United States
Investigational Site Number 840250
🇺🇸Tempe, Arizona, United States
Investigational Site Number 840303
🇺🇸Hot Springs, Arkansas, United States
Investigational Site Number 840184
🇺🇸Jonesboro, Arkansas, United States
Investigational Site Number 840623
🇺🇸Inglewood, California, United States
Investigational Site Number 840606
🇺🇸Long Beach, California, United States
Investigational Site Number 840624
🇺🇸Hawthorne, California, United States
Investigational Site Number 840497
🇺🇸Anaheim, California, United States
Investigational Site Number 840150
🇺🇸Fresno, California, United States
Investigational Site Number 840240
🇺🇸Loma Linda, California, United States
Investigational Site Number 840636
🇺🇸Inglewood, California, United States
Investigational Site Number 840431
🇺🇸Los Angeles, California, United States
Investigational Site Number 840582
🇺🇸Pomona, California, United States
Investigational Site Number 840455
🇺🇸La Mesa, California, United States
Investigational Site Number 840262
🇺🇸Long Beach, California, United States
Investigational Site Number 840290
🇺🇸Mission Viejo, California, United States
Investigational Site Number 840575
🇺🇸San Marino, California, United States
Investigational Site Number 840694
🇺🇸Los Angeles, California, United States
Investigational Site Number 840335
🇺🇸Santa Ana, California, United States
Investigational Site Number 840351
🇺🇸Orange, California, United States
Investigational Site Number 840576
🇺🇸Simi Valley, California, United States
Investigational Site Number 840477
🇺🇸Homosassa, Florida, United States
Investigational Site Number 840466
🇺🇸Roseville, California, United States
Investigational Site Number 840346
🇺🇸Port Hueneme, California, United States
Investigational Site Number 840631
🇺🇸Washington, District of Columbia, United States
Investigational Site Number 840414
🇺🇸Sylmar, California, United States
Investigational Site Number 840281
🇺🇸Clearwater, Florida, United States
Investigational Site Number 840459
🇺🇸Miami, Florida, United States
Investigational Site Number 840432
🇺🇸Oviedo, Florida, United States
Investigational Site Number 840044
🇺🇸Washington, District of Columbia, United States
Investigational Site Number 840318
🇺🇸Panama City, Florida, United States
Investigational Site Number 840206
🇺🇸Vista, California, United States
Investigational Site Number 840350
🇺🇸Whittier, California, United States
Investigational Site Number 840480
🇺🇸Westlake Village, California, United States
Investigational Site Number 840093
🇺🇸Colorado Springs, Colorado, United States
Investigational Site Number 840056
🇺🇸St. Petersburg, Florida, United States
Investigational Site Number 840295
🇺🇸Wellington, Florida, United States
Investigational Site Number 840589
🇺🇸Belleville, Illinois, United States
Investigational Site Number 840107
🇺🇸Chicago, Illinois, United States
Investigational Site Number 840066
🇺🇸Atlanta, Georgia, United States
Investigational Site Number 840534
🇺🇸Columbus, Georgia, United States
Investigational Site Number 840499
🇺🇸Duluth, Georgia, United States
Investigational Site Number 840578
🇺🇸Blue Ridge, Georgia, United States
Investigational Site Number 840519
🇺🇸Arlington Heights, Illinois, United States
Investigational Site Number 840447
🇺🇸Duluth, Georgia, United States
Investigational Site Number 840621
🇺🇸Huntington, Indiana, United States
Investigational Site Number 840681
🇺🇸Peoria, Illinois, United States
Investigational Site Number 840299
🇺🇸Baton Rouge, Louisiana, United States
Investigational Site Number 840345
🇺🇸Joliet, Illinois, United States
Investigational Site Number 840449
🇺🇸Pikeville, Kentucky, United States
Investigational Site Number 840676
🇺🇸Gary, Indiana, United States
Investigational Site Number 840633
🇺🇸Chicago, Illinois, United States
Investigational Site Number 840533
🇺🇸Covington, Kentucky, United States
Investigational Site Number 840043
🇺🇸Annapolis, Maryland, United States
Investigational Site Number 840663
🇺🇸Chicago, Illinois, United States
Investigational Site Number 840212
🇺🇸Hines, Illinois, United States
Investigational Site Number 840251
🇺🇸Madisonville, Kentucky, United States
Investigational Site Number 840360
🇺🇸Elwood, Indiana, United States
Investigational Site Number 840702
🇺🇸Indianapolis, Indiana, United States
Investigational Site Number 840657
🇺🇸Hammond, Indiana, United States
Investigational Site Number 840470
🇺🇸Metairie, Louisiana, United States
Investigational Site Number 840671
🇺🇸Hammond, Louisiana, United States
Investigational Site Number 840639
🇺🇸Catonsville, Maryland, United States
Investigational Site Number 840411
🇺🇸Dearborn, Michigan, United States
Investigational Site Number 840555
🇺🇸Chesterfield, Michigan, United States
Investigational Site Number 840581
🇺🇸Flint, Michigan, United States
Investigational Site Number 840404
🇺🇸Kalamazoo, Michigan, United States
Investigational Site Number 840019
🇺🇸Alpena, Michigan, United States
Investigational Site Number 840640
🇺🇸Takoma Park, Maryland, United States
Investigational Site Number 840219
🇺🇸Duluth, Minnesota, United States
Investigational Site Number 840199
🇺🇸Eagan, Minnesota, United States
Investigational Site Number 840312
🇺🇸Southfield, Michigan, United States
Investigational Site Number 840484
🇺🇸Sterling Heights, Michigan, United States
Investigational Site Number 840091
🇺🇸St. Louis, Missouri, United States
Investigational Site Number 124001
🇨🇦Laval, Canada
Investigational Site Number 840196
🇺🇸Biloxi, Mississippi, United States
Investigational Site Number 840285
🇺🇸Albany, New York, United States
Investigational Site Number 840585
🇺🇸Jamaica, New York, United States
Investigational Site Number 840678
🇺🇸St. Louis, Missouri, United States
Investigational Site Number 840509
🇺🇸Lincoln, Nebraska, United States
Investigational Site Number 840337
🇺🇸Kalispell, Montana, United States
Investigational Site Number 276016
🇩🇪Pohlheim, Germany
Investigational Site Number 840310
🇺🇸Asheville, North Carolina, United States
Investigational Site Number 840454
🇺🇸Calabash, North Carolina, United States
Investigational Site Number 840119
🇺🇸Northport, New York, United States
Investigational Site Number 840543
🇺🇸Columbus, Ohio, United States
Investigational Site Number 840028
🇺🇸Cincinnati, Ohio, United States
Investigational Site Number 840198
🇺🇸Cincinnati, Ohio, United States
Investigational Site Number 840152
🇺🇸Charlotte, North Carolina, United States
Investigational Site Number 840456
🇺🇸Dayton, Ohio, United States
Investigational Site Number 840368
🇺🇸Marion, Ohio, United States
Investigational Site Number 840344
🇺🇸Elizabeth City, North Carolina, United States
Investigational Site Number 840427
🇺🇸Bend, Oregon, United States
Investigational Site Number 276014
🇩🇪Pirna, Germany
Investigational Site Number 840223
🇺🇸Anderson, South Carolina, United States
Investigational Site Number 752007
🇸🇪Stockholm, Sweden
Investigational Site Number 840164
🇺🇸Houston, Texas, United States
Investigational Site Number 840698
🇺🇸El Paso, Texas, United States
Investigational Site Number 840545
🇺🇸Longview, Texas, United States
Investigational Site Number 840439
🇺🇸Fair Oaks Ranch, Texas, United States
Investigational Site Number 032028
🇦🇷Adrogue, Argentina
Investigational Site Number 032043
🇦🇷Bahia Blanca, Argentina
Investigational Site Number 032054
🇦🇷Bahia Blanca, Argentina
Investigational Site Number 032066
🇦🇷Caba, Argentina
Investigational Site Number 840503
🇺🇸Charlottesville, Virginia, United States
Investigational Site Number 840232
🇺🇸American Fork, Utah, United States
Investigational Site Number 840613
🇺🇸Fairmount, Wisconsin, United States
Investigational Site Number 032052
🇦🇷Ciudad Autonoma De Bs.As, Argentina
Investigational Site Number 124024
🇨🇦Calgary, Canada
Investigational Site Number 076024
🇧🇷Belem, Brazil
Investigational Site Number 036016
🇦🇺Townsville, Australia
Investigational Site Number 076006
🇧🇷Belo Horizonte, Brazil
Investigational Site Number 076021
🇧🇷Brasilia, Brazil
Investigational Site Number 076012
🇧🇷Belo Horizonte, Brazil
Investigational Site Number 076002
🇧🇷Campinas, Brazil
Investigational Site Number 036005
🇦🇺St Leonards, Australia
Investigational Site Number 036009
🇦🇺Geelong, Australia
Investigational Site Number 036011
🇦🇺Perth, Australia
Investigational Site Number 076003
🇧🇷Fortaleza, Brazil
Investigational Site Number 036015
🇦🇺Epping, Australia
Investigational Site Number 036001
🇦🇺Fremantle, Australia
Investigational Site Number 076019
🇧🇷Curitiba, Brazil
Investigational Site Number 100002
🇧🇬Byala, Bulgaria
Investigational Site Number 124021
🇨🇦Montreal, Canada
Investigational Site Number 124006
🇨🇦Montreal, Canada
Investigational Site Number 124026
🇨🇦Edmonton, Canada
Investigational Site Number 124016
🇨🇦Cambridge, Canada
Investigational Site Number 124003
🇨🇦St-Marc-Des-Carrieres, Canada
Investigational Site Number 124002
🇨🇦Thetford Mines, Canada
Investigational Site Number 124005
🇨🇦Sudbury, Canada
Investigational Site Number 156016
🇨🇳Beijing, China
Investigational Site Number 170025
🇨🇴Armenia, Colombia
Investigational Site Number 156023
🇨🇳Jinan, China
Investigational Site Number 156015
🇨🇳Jinan, China
Investigational Site Number 156013
🇨🇳Shanghai, China
Investigational Site Number 156019
🇨🇳Shanghai, China
Investigational Site Number 156032
🇨🇳Shenyang, China
Investigational Site Number 156022
🇨🇳Shenyang, China
Investigational Site Number 156004
🇨🇳Suzhou, China
Investigational Site Number 156033
🇨🇳Urumchi, China
Investigational Site Number 156009
🇨🇳Nanjing, China
Investigational Site Number 208009
🇩🇰Aarhus C, Denmark
Investigational Site Number 208003
🇩🇰Aarhus, Denmark
Investigational Site Number 208011
🇩🇰Esbjerg, Denmark
Investigational Site Number 208004
🇩🇰Farsø, Denmark
Investigational Site Number 208002
🇩🇰Hellerup, Denmark
Investigational Site Number 208010
🇩🇰Herlev, Denmark
Investigational Site Number 208008
🇩🇰Hillerød, Denmark
Investigational Site Number 208006
🇩🇰Hvidovre, Denmark
Investigational Site Number 208001
🇩🇰København Nv, Denmark
Investigational Site Number 208005
🇩🇰København S, Denmark
Investigational Site Number 208007
🇩🇰København Ø, Denmark
Investigational Site Number 250008
🇫🇷Brest Cedex, France
Investigational Site Number 250002
🇫🇷Corbeil Essonnes, France
Investigational Site Number 250014
🇫🇷Nimes, France
Investigational Site Number 250007
🇫🇷Paris Cedex 15, France
Investigational Site Number 250011
🇫🇷Pessac, France
Investigational Site Number 276005
🇩🇪Chemnitz, Germany
Investigational Site Number 276003
🇩🇪Berlin, Germany
Investigational Site Number 276022
🇩🇪Bochum, Germany
Investigational Site Number 276024
🇩🇪Dresden, Germany
Investigational Site Number 276007
🇩🇪Elsterwerda, Germany
Investigational Site Number 320004
🇬🇹Guatemala, Guatemala
Investigational Site Number 276017
🇩🇪Görlitz, Germany
Investigational Site Number 276011
🇩🇪Frankfurt Am Main, Germany
Investigational Site Number 276009
🇩🇪Heidelberg, Germany
Investigational Site Number 356016
🇮🇳Cochin, India
Investigational Site Number 356022
🇮🇳Gurgaon, India
Investigational Site Number 380004
🇮🇹Chieri, Italy
Investigational Site Number 410009
🇰🇷Gwangju, Korea, Republic of
Investigational Site Number 410006
🇰🇷Daegu, Korea, Republic of
Investigational Site Number 410008
🇰🇷Incheon, Korea, Republic of
Investigational Site Number 410001
🇰🇷Incheon, Korea, Republic of
Investigational Site Number 428005
🇱🇻Cesis, Latvia
Investigational Site Number 428001
🇱🇻Daugavpils, Latvia
Investigational Site Number 428002
🇱🇻Liepaja, Latvia
Investigational Site Number 410014
🇰🇷Seoul, Korea, Republic of
Investigational Site Number 410002
🇰🇷Seoul, Korea, Republic of
Investigational Site Number 410004
🇰🇷Seongnam, Korea, Republic of
Investigational Site Number 410010
🇰🇷Seoul, Korea, Republic of
Investigational Site Number 724004
🇪🇸Vigo, Spain
Investigational Site Number 578002
🇳🇴Haugesund, Norway
Investigational Site Number 578001
🇳🇴Stavanger, Norway
Investigational Site Number 591001
🇵🇦Cuidad De Panama, Panama
Investigational Site Number 616019
🇵🇱Bydgoszcz, Poland
Investigational Site Number 642033
🇷🇴Pitesti, Romania
Investigational Site Number 724020
🇪🇸Valencia, Spain
Investigational Site Number 158005
🇨🇳Chia-Yi, Taiwan
Investigational Site Number 752004
🇸🇪Stockholm, Sweden
Investigational Site Number 710011
🇿🇦Durban, South Africa
Investigational Site Number 710008
🇿🇦Chatsworth, South Africa
Investigational Site Number 710023
🇿🇦Parow, South Africa
Investigational Site Number 710002
🇿🇦Pretoria, South Africa
Investigational Site Number 710020
🇿🇦Alberton, South Africa
Investigational Site Number 710017
🇿🇦Cape Town, South Africa
Investigational Site Number 710006
🇿🇦Cape Town, South Africa
Investigational Site Number 710025
🇿🇦Cape Town, South Africa
Investigational Site Number 710014
🇿🇦Paarl, South Africa
Investigational Site Number 724005
🇪🇸Alcalá De Henares, Spain
Investigational Site Number 724016
🇪🇸Almería, Spain
Investigational Site Number 724012
🇪🇸Barakaldo, Spain
Investigational Site Number 792004
🇹🇷Ankara, Turkey
Investigational Site Number 792002
🇹🇷Ankara, Turkey
Investigational Site Number 792012
🇹🇷Ankara, Turkey
Investigational Site Number 792001
🇹🇷Capa / Istanbul, Turkey
Investigational Site Number 792015
🇹🇷Istanbul, Turkey
Investigational Site Number 792008
🇹🇷Istanbul, Turkey
Investigational Site Number 792014
🇹🇷Istanbul, Turkey
Investigational Site Number 792003
🇹🇷Izmir, Turkey
Investigational Site Number 792007
🇹🇷Izmir, Turkey
Investigational Site Number 792011
🇹🇷Mersin, Turkey
Investigational Site Number 792013
🇹🇷Samsun, Turkey
Investigational Site Number 840009
🇺🇸Topeka, Kansas, United States
Investigational Site Number 840382
🇺🇸Las Vegas, Nevada, United States
Investigational Site Number 840680
🇺🇸Las Vegas, Nevada, United States
Investigational Site Number 840217
🇺🇸Las Vegas, Nevada, United States
Investigational Site Number 840096
🇺🇸Nashville, Tennessee, United States
Investigational Site Number 840388
🇺🇸Nashville, Tennessee, United States
Investigational Site Number 840506
🇺🇸Phoenix, Arizona, United States
Investigational Site Number 840322
🇺🇸Phoenix, Arizona, United States
Investigational Site Number 840205
🇺🇸Detroit, Michigan, United States
Investigational Site Number 840415
🇺🇸Birmingham, Alabama, United States
Investigational Site Number 840511
🇺🇸Portland, Oregon, United States
Investigational Site Number 840422
🇺🇸Portland, Oregon, United States
Investigational Site Number 250012
🇫🇷Poitiers Cedex, France
Investigational Site Number 250006
🇫🇷Rennes, France
Investigational Site Number 250001
🇫🇷Toulouse Cedex 4, France
Investigational Site Number 380002
🇮🇹Chieti, Italy
Investigational Site Number 380016
🇮🇹Messina, Italy
Investigational Site Number 380023
🇮🇹Milano, Italy
Investigational Site Number 380012
🇮🇹Milano, Italy
Investigational Site Number 380013
🇮🇹Roma, Italy
Investigational Site Number 380014
🇮🇹Napoli, Italy
Investigational Site Number 380019
🇮🇹Novara, Italy
Investigational Site Number 380005
🇮🇹Palermo, Italy
Investigational Site Number 826042
🇬🇧Antrim, United Kingdom
Investigational Site Number 826002
🇬🇧Ashton-Under-Lyne, United Kingdom
Investigational Site Number 826026
🇬🇧Barnstaple, United Kingdom
Investigational Site Number 826017
🇬🇧Bath, United Kingdom
Investigational Site Number 826034
🇬🇧Birmingham, United Kingdom
Investigational Site Number 826048
🇬🇧Carmarthen, United Kingdom
Investigational Site Number 826037
🇬🇧Chester, United Kingdom
Investigational Site Number 826044
🇬🇧East Kilbride, United Kingdom
Investigational Site Number 826023
🇬🇧Edinburgh, United Kingdom
Investigational Site Number 826008
🇬🇧Glasgow, United Kingdom
Investigational Site Number 826010
🇬🇧Harrogate, United Kingdom
Investigational Site Number 826040
🇬🇧Ipswich, United Kingdom
Investigational Site Number 826033
🇬🇧Larbert, United Kingdom
Investigational Site Number 826027
🇬🇧Liverpool, United Kingdom
Investigational Site Number 826039
🇬🇧Londonderry, United Kingdom
Investigational Site Number 826021
🇬🇧Manchester, United Kingdom
Investigational Site Number 826020
🇬🇧Nuneaton, United Kingdom
Investigational Site Number 826009
🇬🇧Oldham, United Kingdom
Investigational Site Number 826007
🇬🇧Salford, United Kingdom
Investigational Site Number 826045
🇬🇧Stoke-On-Trent, United Kingdom
Investigational Site Number 826038
🇬🇧Swansea, United Kingdom
Investigational Site Number 826018
🇬🇧Taunton, United Kingdom
Investigational Site Number 826006
🇬🇧Manchester, United Kingdom
Investigational Site Number 826016
🇬🇧Truro, United Kingdom
Investigational Site Number 826046
🇬🇧Wolverhampton, United Kingdom
Investigational Site Number 826019
🇬🇧Yeovil, United Kingdom
Investigational Site Number 124027
🇨🇦Oshawa, Canada
Investigational Site Number 124025
🇨🇦Quebec, Canada
Investigational Site Number 124028
🇨🇦Red Deer, Canada
Investigational Site Number 124007
🇨🇦Sarnia, Canada
Investigational Site Number 076018
🇧🇷Fortaleza, Brazil
Investigational Site Number 076004
🇧🇷Fortaleza, Brazil
Investigational Site Number 076023
🇧🇷Goiania, Brazil
Investigational Site Number 076014
🇧🇷Marilia, Brazil
Investigational Site Number 076015
🇧🇷Passo Fundo, Brazil
Investigational Site Number 076008
🇧🇷Porto Alegre, Brazil
Investigational Site Number 076025
🇧🇷Recife, Brazil
Investigational Site Number 076020
🇧🇷Salvador, Brazil
Investigational Site Number 076013
🇧🇷Porto Alegre, Brazil
Investigational Site Number 076016
🇧🇷Sao Paulo, Brazil
Investigational Site Number 076010
🇧🇷Sao Paulo, Brazil
Investigational Site Number 076001
🇧🇷Sao Paulo, Brazil
Investigational Site Number 076005
🇧🇷Sao Paulo, Brazil
Investigational Site Number 076007
🇧🇷Uberlandia, Brazil
Investigational Site Number 710001
🇿🇦Pretoria, South Africa
Investigational Site Number 710005
🇿🇦Richards Bay, South Africa
Investigational Site Number 710007
🇿🇦Somerset West, South Africa
Investigational Site Number 710004
🇿🇦Worcester, South Africa
Investigational Site Number 840007
🇺🇸Omaha, Nebraska, United States
Investigational Site Number 840493
🇺🇸Milwaukee, Wisconsin, United States
Investigational Site Number 840046
🇺🇸St. Louis, Missouri, United States
Investigational Site Number 840400
🇺🇸St. Louis, Missouri, United States
Investigational Site Number 276026
🇩🇪Rotenburg An Der Fulda, Germany
Investigational Site Number 840348
🇺🇸Mineola, New York, United States
Investigational Site Number 840696
🇺🇸Rosedale, New York, United States
Investigational Site Number 276025
🇩🇪Haßloch, Germany
Investigational Site Number 276018
🇩🇪Frankfurt A.M., Germany
Investigational Site Number 840286
🇺🇸Roanoke, Virginia, United States
Investigational Site Number 840654
🇺🇸Oakland, California, United States
Investigational Site Number 840689
🇺🇸Orange, California, United States
Investigational Site Number 840401
🇺🇸Pittsburgh, Pennsylvania, United States
Investigational Site Number 840464
🇺🇸Clark Summit, Pennsylvania, United States
Investigational Site Number 840473
🇺🇸Dallas, Texas, United States
Investigational Site Number 840573
🇺🇸San Antonio, Texas, United States
Investigational Site Number 840608
🇺🇸Richmond, Texas, United States
Investigational Site Number 840174
🇺🇸Marshall, Texas, United States
Investigational Site Number 840266
🇺🇸Providence, Rhode Island, United States
Investigational Site Number 840677
🇺🇸Edinburg, Texas, United States
Investigational Site Number 840530
🇺🇸Lubbock, Texas, United States
Investigational Site Number 840385
🇺🇸Lubbock, Texas, United States
Investigational Site Number 840565
🇺🇸Plano, Texas, United States
Investigational Site Number 840564
🇺🇸Sugarland, Texas, United States
Investigational Site Number 840023
🇺🇸Little Rock, Arkansas, United States
Investigational Site Number 840520
🇺🇸Phoenix, Arizona, United States
Investigational Site Number 840393
🇺🇸Toney, Alabama, United States
Investigational Site Number 840361
🇺🇸Little Rock, Arkansas, United States
Investigational Site Number 840314
🇺🇸Merced, California, United States
Investigational Site Number 840135
🇺🇸Los Angeles, California, United States
Investigational Site Number 840592
🇺🇸National City, California, United States
Investigational Site Number 840352
🇺🇸Buckley, Michigan, United States
Investigational Site Number 032049
🇦🇷Caba, Argentina
Investigational Site Number 032011
🇦🇷Cordoba, Argentina
Investigational Site Number 840045
🇺🇸Norfolk, Virginia, United States
Investigational Site Number 032033
🇦🇷San Nicolas, Argentina
Investigational Site Number 032045
🇦🇷Santa Fe, Argentina
Investigational Site Number 032022
🇦🇷Cordoba, Argentina
Investigational Site Number 032018
🇦🇷Corrientes, Argentina
Investigational Site Number 032023
🇦🇷Qilmes, Argentina
Investigational Site Number 840128
🇺🇸Chesapeake, Virginia, United States
Investigational Site Number 032024
🇦🇷Ramos Mejia, Argentina
Investigational Site Number 840343
🇺🇸Spokane, Washington, United States
Investigational Site Number 840465
🇺🇸Chesapeake, Virginia, United States
Investigational Site Number 032040
🇦🇷Lanus, Argentina
Investigational Site Number 032002
🇦🇷Parana, Argentina
Investigational Site Number 032030
🇦🇷Bahia Blanca, Argentina
Investigational Site Number 840094
🇺🇸Spokane, Washington, United States
Investigational Site Number 032019
🇦🇷Junin, Argentina
Investigational Site Number 100003
🇧🇬Plovdiv, Bulgaria
Investigational Site Number 100006
🇧🇬Lovech, Bulgaria
Investigational Site Number 100004
🇧🇬Pleven, Bulgaria
Investigational Site Number 268003
🇬🇪Batumi, Georgia
Investigational Site Number 268004
🇬🇪Kutaisi, Georgia
Investigational Site Number 233002
🇪🇪Tallinn, Estonia
Investigational Site Number 246010
🇫🇮Tampere, Finland
Investigational Site Number 250005
🇫🇷Nantes, France
Investigational Site Number 276021
🇩🇪Dresden, Germany
Investigational Site Number 276019
🇩🇪Leipzig, Germany
Investigational Site Number 276028
🇩🇪Mühldorf Am Inn, Germany
Investigational Site Number 276020
🇩🇪Magdeburg, Germany
Investigational Site Number 356014
🇮🇳Lucknow, India
Investigational Site Number 356032
🇮🇳Mangalore, India
Investigational Site Number 356023
🇮🇳Mysore, India
Investigational Site Number 356006
🇮🇳Nagpur, India
Investigational Site Number 356030
🇮🇳Nasik, India
Investigational Site Number 376002
🇮🇱Haifa, Israel
Investigational Site Number 320011
🇬🇹Guatemala, Guatemala
Investigational Site Number 356031
🇮🇳Jaipur, India
Investigational Site Number 356015
🇮🇳Lucknow, India
Investigational Site Number 356002
🇮🇳Bangalore, India
Investigational Site Number 356024
🇮🇳Belgaum, India
Investigational Site Number 356004
🇮🇳Kolkata, India
Investigational Site Number 356025
🇮🇳Madurai, India
Investigational Site Number 356010
🇮🇳Bangalore, India
Investigational Site Number 356029
🇮🇳Hubli, India
Investigational Site Number 356009
🇮🇳Ludhiana, India
Investigational Site Number 356018
🇮🇳Manipal, India
Investigational Site Number 356034
🇮🇳Nashik, India
Investigational Site Number 356013
🇮🇳New Delhi, India
Investigational Site Number 356017
🇮🇳New Delhi, India
Investigational Site Number 376008
🇮🇱Haifa, Israel
Investigational Site Number 376012
🇮🇱Jerusalem, Israel
Investigational Site Number 376005
🇮🇱Safed, Israel
Investigational Site Number 392025
🇯🇵Hachioji-Shi, Japan
Investigational Site Number 380009
🇮🇹Genova, Italy
Investigational Site Number 380001
🇮🇹Pisa, Italy
Investigational Site Number 380020
🇮🇹Rozzano, Italy
Investigational Site Number 356021
🇮🇳Pune, India
Investigational Site Number 356028
🇮🇳Pune, India
Investigational Site Number 376010
🇮🇱Afula, Israel
Investigational Site Number 376006
🇮🇱Givatayim, Israel
Investigational Site Number 376004
🇮🇱Tel Aviv, Israel
Investigational Site Number 376009
🇮🇱Tzrifin, Israel
Investigational Site Number 380011
🇮🇹Milano, Italy
Investigational Site Number 392015
🇯🇵Fuchu-Shi, Japan
Investigational Site Number 392003
🇯🇵Itabashi-Ku, Japan
Investigational Site Number 392019
🇯🇵Kawanishi-Shi, Japan
Investigational Site Number 392009
🇯🇵Nagasaki-Shi, Japan
Investigational Site Number 380024
🇮🇹Carpi, Italy
Investigational Site Number 484033
🇲🇽Aguascalientes, Mexico
Investigational Site Number 392011
🇯🇵Chuo-Ku, Japan
Investigational Site Number 392012
🇯🇵Fujisawa-Shi, Japan
Investigational Site Number 380006
🇮🇹Fermo, Italy
Investigational Site Number 380010
🇮🇹Firenze, Italy
Investigational Site Number 392022
🇯🇵Hitachi-Shi, Japan
Investigational Site Number 392007
🇯🇵Matsuyama-Shi, Japan
Investigational Site Number 392008
🇯🇵Matsuyama-Shi, Japan
Investigational Site Number 392020
🇯🇵Osaka-Shi, Japan
Investigational Site Number 392005
🇯🇵Hamamatsu-Shi, Japan
Investigational Site Number 392017
🇯🇵Itabashi-Ku, Japan
Investigational Site Number 392013
🇯🇵Kobe-Shi, Japan
Investigational Site Number 440005
🇱🇹Panevezys, Lithuania
Investigational Site Number 440001
🇱🇹Vilnius, Lithuania
Investigational Site Number 484011
🇲🇽Acapulco, Mexico
Investigational Site Number 484008
🇲🇽Aguascalientes, Mexico
Investigational Site Number 484041
🇲🇽Durango, Mexico
Investigational Site Number 484014
🇲🇽Guadalajara, Mexico
Investigational Site Number 484028
🇲🇽Guadalajara, Mexico
Investigational Site Number 604017
🇵🇪Lima, Peru
Investigational Site Number 410012
🇰🇷Bucheon, Korea, Republic of
Investigational Site Number 440002
🇱🇹Kaunas, Lithuania
Investigational Site Number 410007
🇰🇷Wonju, Korea, Republic of
Investigational Site Number 410013
🇰🇷Seoul, Korea, Republic of
Investigational Site Number 410011
🇰🇷Seoul, Korea, Republic of
Investigational Site Number 484023
🇲🇽Ciudad Madero, Mexico
Investigational Site Number 591003
🇵🇦Cuidad De Panama, Panama
Investigational Site Number 604016
🇵🇪Lima, Peru
Investigational Site Number 616008
🇵🇱Bialystok, Poland
Investigational Site Number 608005
🇵🇭Marikina City, Philippines
Investigational Site Number 642026
🇷🇴Cluj Napoca, Romania
Investigational Site Number 616005
🇵🇱?ód?, Poland
Investigational Site Number 724017
🇪🇸Murcia, Spain
Investigational Site Number 710010
🇿🇦Cape Town, South Africa
Investigational Site Number 643016
🇷🇺Tver, Russian Federation
Investigational Site Number 752002
🇸🇪Växjö, Sweden
Investigational Site Number 642015
🇷🇴Craiova, Romania
Investigational Site Number 643014
🇷🇺Smolensk, Russian Federation
Investigational Site Number 643031
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643036
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643010
🇷🇺Saratov, Russian Federation
Investigational Site Number 643033
🇷🇺Saratov, Russian Federation
Investigational Site Number 643019
🇷🇺Saratov, Russian Federation
Investigational Site Number 643041
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643028
🇷🇺Tomsk, Russian Federation
Investigational Site Number 616029
🇵🇱Leczyca, Poland
Investigational Site Number 642030
🇷🇴Craiova, Romania
Investigational Site Number 643012
🇷🇺Tyumen, Russian Federation
Investigational Site Number 688006
🇷🇸Belgrade, Serbia
Investigational Site Number 643059
🇷🇺Vladimir, Russian Federation
Investigational Site Number 724003
🇪🇸Pontevedra, Spain
Investigational Site Number 752012
🇸🇪Karlstad, Sweden
Investigational Site Number 752006
🇸🇪Ljungby, Sweden
Investigational Site Number 752009
🇸🇪Oskarshamn, Sweden
Investigational Site Number 688004
🇷🇸Belgrade, Serbia
Investigational Site Number 643056
🇷🇺Saratov, Russian Federation
Investigational Site Number 724011
🇪🇸Madrid, Spain
Investigational Site Number 724008
🇪🇸Lérida, Spain
Investigational Site Number 724015
🇪🇸Cáceres, Spain
Investigational Site Number 642007
🇷🇴Deva, Romania
Investigational Site Number 642011
🇷🇴Iasi, Romania
Investigational Site Number 642014
🇷🇴Targu Mures, Romania
Investigational Site Number 643024
🇷🇺St-Petersburg, Russian Federation
Investigational Site Number 643062
🇷🇺Yaroslavl, Russian Federation
Investigational Site Number 724014
🇪🇸Bilbao, Spain
Investigational Site Number 688010
🇷🇸Belgrade, Serbia
Investigational Site Number 688007
🇷🇸Nis, Serbia
Investigational Site Number 724018
🇪🇸Barcelona, Spain
Investigational Site Number 724013
🇪🇸La Coruña, Spain
Investigational Site Number 710015
🇿🇦George, South Africa
Investigational Site Number 710019
🇿🇦Kempton Park, South Africa
Investigational Site Number 724022
🇪🇸Oviedo, Spain
Investigational Site Number 724001
🇪🇸Sevilla, Spain
Investigational Site Number 752011
🇸🇪Kristianstad, Sweden
Investigational Site Number 804011
🇺🇦Kiev, Ukraine
Investigational Site Number 826005
🇬🇧Bradford, United Kingdom
Investigational Site Number 826011
🇬🇧Dumfries, United Kingdom
Investigational Site Number 826049
🇬🇧Norwich, United Kingdom
Investigational Site Number 826036
🇬🇧Manchester, United Kingdom
Investigational Site Number 158002
🇨🇳Taipei, Taiwan
Investigational Site Number 826052
🇬🇧Bolton, United Kingdom
Investigational Site Number 840328
🇺🇸Greensboro, North Carolina, United States
Investigational Site Number 840513
🇺🇸Greensboro, North Carolina, United States
Investigational Site Number 840504
🇺🇸Greenville, North Carolina, United States
Investigational Site Number 840642
🇺🇸Monroe, North Carolina, United States
Investigational Site Number 840672
🇺🇸Charlotte, North Carolina, United States
Investigational Site Number 840481
🇺🇸Raleigh, North Carolina, United States
Investigational Site Number 840381
🇺🇸Wilmington, North Carolina, United States
Investigational Site Number 840532
🇺🇸Winston Salem, North Carolina, United States
Investigational Site Number 156014
🇨🇳Beijing, China
Investigational Site Number 156028
🇨🇳Beijing, China
Investigational Site Number 643060
🇷🇺Moscow, Russian Federation
Investigational Site Number 840241
🇺🇸Waco, Texas, United States
Investigational Site Number 840213
🇺🇸Norfolk, Virginia, United States
Investigational Site Number 840001
🇺🇸Richmond, Virginia, United States
Investigational Site Number 840268
🇺🇸Spokane, Washington, United States
Investigational Site Number 076026
🇧🇷Porto Alegre, Brazil
Investigational Site Number 840061
🇺🇸Tacoma, Washington, United States
Investigational Site Number 840121
🇺🇸Lacrosse, Wisconsin, United States
Investigational Site Number 840445
🇺🇸Kansas City, Missouri, United States
Investigational Site Number 840008
🇺🇸Kansas City, Missouri, United States
Investigational Site Number 840560
🇺🇸Butler, Pennsylvania, United States
Investigational Site Number 840180
🇺🇸Chesapeake, Virginia, United States
Investigational Site Number 840471
🇺🇸Draper, Utah, United States
Investigational Site Number 840170
🇺🇸Olympia, Washington, United States
Investigational Site Number 840275
🇺🇸Northridge, California, United States
Investigational Site Number 840395
🇺🇸Ventura, California, United States