A Global Approach to Tackle Cognitive Decline
- Conditions
- Dementia
- Registration Number
- NCT05479318
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
The number of people suffering from dementia in Asia (22.9 million) is more than twice the numbers in Europe (10.5 million) or the Americas (9.4 million), as recorded in the global impact of dementia in the World Alzheimer Report 2015.1 This dementia tsunami will continue to rise and the estimated number is 67 million in 2050 in Asia alone, which will be 2 to 3 times higher than the estimates for Europe (19 million) or the Americas (30 million). Devising and implementing preventive strategies against dementia is of paramount importance. The proposed project will be able to establish the associations between VRFs and cognition across cohorts with cultural, ethnical, and demographical variations. This study will generate data for evidence-based knowledge for globally implementable and effective preventive strategies for cognitive impairment and dementia.
- Detailed Description
Participants will be retrospectively selected from a Hong Kong Chinese cohort, a Singaporean cohort, a British cohort, two European cohorts, and an Australian cohort.
Subjects from the above listed cohorts who fit the study criteria will be selected for this study.
Demographical information, clinical, vascular risk factors, MRI images and cognitive data will be retrieved from the cohorts.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1502
- Elderly community-dwelling individuals aged over 60 years old;
- those with at least 2 time points of detailed cognitive measurements, with 2-3 years of assessment interval;
- with at least 1 timepoint of MRI (T1, FLAIR, and DTI).
- subjects with stroke, dementia, and other neurological diseases at baseline;
- those without longitudinal cognitive data;
- those without MRI data available.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Record of blood pressure Baseline Blood pressure, as one of vascular risk factors, unit as mmHg
Record of any vascular risk factors Baseline medical history of hypertension, diabetes mellitus, hyperlipidemia, smoking and drinking, record unit as yes or no
Record of low-density-lipoprotein level, Baseline low-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L
Record of total cholesterol level, Baseline total cholesterol level, as one of the vascular risk factors, unit as mmol/L
Record of pulse Baseline Pulse rate, as one of vascular risk factors, unit as bpm
Record of triglyceride level Baseline triglyceride level, as one of vascular risk factors, unit as mmol/L
Record of high-density-lipoprotein level, Baseline high-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L
Record of fasting blood glucose Baseline fasting blood glucose from blood results, as one of vascular risk factors, unit as mmol/L
Record of glycated hemoglobin Baseline glycated hemoglobin, as one of the vascular risk factors, unit as percentage
Change of Montreal Cognitive Assessment Baseline, 1 yr, 2yr and 3rd year follow ups Montreal Cognitive Assessment is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.
Changes of brain white matter abnormalities Baseline and 1 yr, 2yr and 3rd year follow ups brain white matter abnormalities can be observed through the FLAIR sequence of brain MRI images
Change of Mini-Mental State Examination Baseline and 3rd year follow up Mini-Mental State Examination is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Prince of Wales Hospital
ðŸ‡ðŸ‡°Shatin, N.t., Hong Kong