Standardization of brain atrophy measurement in MS patients

Completed

• Conditions: Multiple Sclerosis; 10012303

• Registration Number: NL-OMON43474
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 35

Inclusion Criteria

MS patient group:
1. Diagnosis of relapsing-remitting, secondary progressive, or primary progressive MS.
2. 18 to 70 years old.
3. Written informed consent;Healthy controls:
1. 18 to 70 years old.
2. Written informed consent

Exclusion Criteria

1. Inability to undergo MRI, e.g. metal objects in or around the body, claustrophobia or inability to lie still in the scanner.
2. Pregnant
3. Any (relevant) neurological disease (for healthy subjects).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quantitative measures (median absolute difference, limits of agreement) of the<br /><br>inter-scanner and intra-scanner variability of measurements of the 1-year<br /><br>volume change of putamen, caudate nucleus, and the entire cerebrum using the<br /><br>new, standardised method.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The same quantitative measures of reproducibility for other, widely used<br /><br>methods to measure the volume change, specifically for the software Siena,<br /><br>FIRST and FreeSurfer.</p><br>