Meta-cognitive Therapy (MCT) versus Cognitive Behaviour Therapy (CBT) for Depressio

Not Applicable

Completed

• Conditions: Depression; Mental and Behavioural Disorders; Depressive episode

• Registration Number: ISRCTN82799488
• Lead Sponsor: niversity of Manchester (UK)

Brief Summary

2020 results in https://pubmed.ncbi.nlm.nih.gov/32398710 (added 12/05/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-04
• Study Completion: 2017-06-01
• Last Update Posted: 1 June 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 174

Inclusion Criteria

1. Patients (male and female, aged 18-68 years) who have a main or primary diagnosis of major depressive disorder (MDD) according to Structured Clinical Interview for DSM-IV Disorders (SCID) I.
2. Patients who only attend therapy in this trial and have not received other psychological treatments for the current episode.
3. Patients in combined medical treatment as long as they are stable or willing to remain stable on their medication for the period of the trial.
4. Patients who sign informed consent

Exclusion Criteria

1. Patients suffering from psychosis or bipolar disorder as screened by SCID I
2. Patients suffering from substance and alcohol-abuse as screened by SCID I
3. Patients suffering from borderline personality disorder as screened by SCID II
4. Patients with organic brain syndrome or mental retardation
5. Female patients who are pregnant or lactating
6. Participants who had not responded favorably to an earlier adequate trial of either CBT or MCT

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Depressive symptoms (Hamilton Depression Inventory administered by blind assessor)<br> 2. Depressive symptoms on self report questionnaire (Beck Depression Inventory ? BDI-II<br><br> Measured before, mid, post and at 6 months follow-up.<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Anxiety related symptoms (Beck Anxiety Inventory - BAI)<br> 2. Co-morbidity (SCID I)<br> 3. Patients? expectancies about treatment outcome<br> 4. Meta-cognitive scales (Meta-cognitive Questionnaire - MCQ-30, negative and positive beliefs about rumination scales (NBRS PBRS), Rumination Response Scale (RRS)<br> 5. CBT specific scales (Dysfunctional Attitude Scale DAS and Young?s Schema Inventory - short version)<br> 6. Patient-therapist alliance (Havarth Aliance Inventory HAI)<br> 7. Objective measure (Concentration and attention subtests from the WAIS)<br><br> Measured before, mid, post and at 6 months follow-up.<br>