Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT
- Conditions
- Carotid Atherosclerosis
- Interventions
- Other: PET-CT with CuATSM
- Registration Number
- NCT01000181
- Lead Sponsor
- King's College London
- Brief Summary
The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile. It is important to determine which patients are most at risk so that surgery can be performed. There is evidence that the risk is greatest when these plaques become oxygen deficient (hypoxic). The investigators wish to use PET imaging to identify hypoxic plaque, to help decide whether and when to perform surgery. The investigators have developed radiotracers (imaging agents) for this purpose, and this study is to determine whether they will work in patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 10
- Male/Female patients who are 55yrs or older and for whom carotid endarterectomy is clinically indicated and a decision has been made to perform a carotid endarterectomy.
- Normal liver and adequate renal function. Assessed by measuring eGFR (>50ml/min) and creatinine (<130μmol/L)
- Life expectancy > 12 weeks
- Patients should be able to tolerate head/neck mask as well as lying in the PET-CT scanner
- Abnormal liver and renal function (eGFR <50ml/min, Creatinine >130μmol/L)
- Patient unwilling to provide written informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients undergoing carotid endarterectomy PET-CT with CuATSM -
- Primary Outcome Measures
Name Time Method Uptake of CuATSM in carotid plaque Within 30 days of carotid endarterectomy
- Secondary Outcome Measures
Name Time Method Relationship of CuATSM uptake to plaque histology Within 30 days of carotid endarterectomy
Trial Locations
- Locations (1)
St Thomas' Hospital
🇬🇧London, United Kingdom
St Thomas' Hospital🇬🇧London, United Kingdom