Continuous use of Oral contraceptives as an alternative for long term Pituitary down-regulation with a GnRH agonist prior to IVF/ICSI in Endometriosis patients: a randomised controlled trial
Recruiting
- Conditions
- Endometriosis, Assisted Reproductive Techniques, IVF, Pregnancy, Cost-Effectiveness, Subfertility, Infertility
- Registration Number
- NL-OMON26777
- Lead Sponsor
- VU University Medical Center
- Brief Summary
.a.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
Patients with presence of endometriosis (ASRM III-IV) confirmed by previous surgery or likely to be present based on TVUS or MRI (including presence of uni- or bilateral ovarian endometrioma and deep endometriosis).
- Scheduled for first, second or third IVF or ICSI treatment cycle
Exclusion Criteria
- Patients aged over 41 years (excluding patients from the day they have celebrated their 41 year birthday).
- Patients with known contraindications for oral contraceptives (history of VTE, positive family history for VTE and/or known thrombophilic abnormalities) or GnRH agonists.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ive birth rate after fresh embryo transfer.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are cumulative live birth rate after one IVF/ICSI treatment cycle including fresh and frozen embryo transfers up to 15 months after randomization, ongoing pregnancy rate, time to pregnancy, treatment outcome parameters (like number of oocytes), adverse events, complications, recurrences, quality of life, safety and costs effectiveness.