Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- Quantification of cytokine concentrations in samples by ELISA
研究概览
简要总结
Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
patients are anonymized
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age Limits (18-80 years)
- •Information and non-opposition for participating in the study
- •Patients suffering from periodontitis grade III ou IV
- •Patients suffering from microcristalline arthritis
- •patient with health insurance
排除标准
- •patient under corticotherapy
- •pregnancy
- •non-compliant patient
- •patient with no health insurance
- •patient in exclusion period from an other study
- •legal incapacity
结局指标
主要结局
Quantification of cytokine concentrations in samples by ELISA
时间窗: up to 2 months
次要结局
未报告次要终点