Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages
- Conditions
- Inflammation
- Interventions
- Procedure: blood sample or joint fluid or gingival exudate
- Registration Number
- NCT05106075
- Lead Sponsor
- Centre Hospitalier Universitaire de Besancon
- Brief Summary
Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Age Limits (18-80 years)
- Information and non-opposition for participating in the study
- Patients suffering from periodontitis grade III ou IV
- Patients suffering from microcristalline arthritis
- patient with health insurance
- patient under corticotherapy
- pregnancy
- non-compliant patient
- patient with no health insurance
- patient in exclusion period from an other study
- legal incapacity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description biologic sample collection blood sample or joint fluid or gingival exudate Blood samples or gingival exsudat collection
- Primary Outcome Measures
Name Time Method Quantification of cytokine concentrations in samples by ELISA up to 2 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Dentist'S Office
🇫🇷Montbéliard, France
CHRU Besançon
🇫🇷Besançon, France