Clinical Feasibility of Abbreviated MRI for Surveillance in High Risk Group for Developing Pancreas Cancer: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Detection of pancreas cancer
研究概览
简要总结
This study aims to establish a prospective cohort of developing pancreas cancer and surveillance MRI protocol. With the focused surveillance protocol, we perform surveillance for pancreas cancer for five years to estimate the risk of pancreas cancer and the clinical feasibility of the surveillance MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •On follow-up due to first degree-family history of PAC
- •Or on follow-up for BD-IPMN (>= 2 cm) or main-duct type IPMN (> 5 mm)
- •And signed informed consent
排除标准
- •Contra-indication of performing MRI
- •Not satisfying the selection criteria.
- •Previously diagnosed with pancreatic malignancy
- •Pregnancy or planning pregnancy
研究组 & 干预措施
Abbreviated PB MRI
Short and Focused non-contrast MRI for surveillance
干预措施: Abbreviated PB MRI (Diagnostic Test)
Abbreviated PB MRI
Short and Focused non-contrast MRI for surveillance
干预措施: Gene mutation test (Genetic)
Abbreviated PB MRI
Short and Focused non-contrast MRI for surveillance
干预措施: Conventional follow-up (Diagnostic Test)
结局指标
主要结局
Detection of pancreas cancer
时间窗: 1 year after the last surveillance MRI.
number of detected pancreas cancer (resectable \& BRPC only) in surveillance MRI.
次要结局
- Estimation of pancreas cancer risk(1 year after the last surveillance MRI.)
- Scan time of abbreviated PB MRI for surveillance(1 month after the first surveillance MRI.)
- Detection of pancreas cancer(1 year after the last surveillance MRI.)
研究者
Jeong Min Lee
Professor
Seoul National University Hospital