Effects of Quercetin on Cardiometabolic Outcomes
- Conditions
- Cardiometabolic Syndrome
- Interventions
- Dietary Supplement: QuercetinOther: Placebo
- Registration Number
- NCT06230861
- Lead Sponsor
- University of Central Lancashire
- Brief Summary
Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. It has been postulated that Quercetin may be beneficial in improving cardiometabolic outcomes. However, to date, no research has explored this using a placebo randomized intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 36
- Healthy
- Between 18 & 65 years
- Non-smoker
- BMI < 30
- Able to give informed consent
- Pregnancy
- Diabetes or any other metabolic/ uncontrolled hypertensive conditions
- Food allergies to quercetin
- Habitual consumption of quercetin
- Not regularly taking medication or antioxidant supplements
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Quercetin tablets 500mg 1 x pe Quercetin Quercetin tablets 500mg 1 x per day Placebo Placebo -
- Primary Outcome Measures
Name Time Method Systolic blood pressure 20 days Systolic blood pressure - measured using a digital blood pressure monitor
- Secondary Outcome Measures
Name Time Method Blood glucose 20 days Capillary blood glucose - mmol/L
Pittsburgh Sleep Quality Index 20 days Sleep quality - The Pittsburgh Sleep Quality index, is a questionnaire that consists of 19 self-rated questions, grouped into 7 components. Each component is scored separately, weighted equally on a 0 - 3 scale and the scores of the 7 components are then added to give a global score, which has a range of 0 - 21 with higher scores indicating worse sleep quality.
Waist to hip ratio 20 days Ratio of waist to hip circumference - measured using anthropocentric tape
Blood triglycerides 20 days Capillary blood triglycerides - mmol/L
Triglyceride glucose index 20 days Calculated as the natural logarithm of (blood triglycerides x blood glucose) /2)
Coop-Wonka chart 20 days Psychological wellbeing - The Coop-Wonka chart is a six item questionnaire with a 1-5 scoring
State Trait Anxiety Inventory 20 days Psychological wellbeing - the state trait anxiety inventory is a 40 item questionnaire with each question having a 1-4 score system, thus the maximum score is 80 which indicates the highest level of anxiety.
Percent bodyfat 20 days Participants percentage composition of fat - measured using bio-electrical impedance
Diastolic blood pressure 20 days Diastolic blood pressure - measured using a digital blood pressure monitor
Blood cholesterol (Total, HDL & LDL) 20 days Capillary blood cholesterol - mmol/L
Epworth Sleepiness Scale 20 days Sleep quality - The Epworth Sleepiness Scale is a self-administered questionnaire with 8 questions. Respondents are asked to rate, on a 4-point scale (0-3) with a maximum score of 24.
Beck Depression Inventory 20 days Psychological wellbeing - the Beck Depression Inventory is a 21 questionnaire with questions that range in scoring from 0-3, thus the maximum score is 63 which is the highest depression score possible.
Insomnia Severity Index 20 days Sleep quality - The Insomnia Severity Index is a brief instrument designed to assess the severity of both nighttime and daytime components of insomnia. The Insomnia Severity Index is a 7-item self-report questionnaire yielding a total score ranging from 0 to 28.
Trial Locations
- Locations (1)
University of Central Lancashire
🇬🇧Preston, Lancashire, United Kingdom