临床试验/NCT03366597

NCT03366597Unknown不适用

Effect of Sevoflurane on the Content of S100β in Infants With Congenital Heart Disease Undergo Cardiac Surgery.

Jun Ma1 个研究点分布在 1 个国家目标入组 100 人开始时间: 2018年1月20日最近更新: 2021年2月11日

适应症

干预措施

试验速览

阶段: 不适用
发起方
入组人数: 100
试验地点: 1
主要终点: Concentration of S100β protein

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

To observe the effect of sevoflurane on the concentration of S100β and regional cerebral oxygen saturation in infants with congenital heart disease undergoing cardiac surgery.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: — 至 3 Years（Child）
性别: All
接受健康志愿者: 否

入选标准

•Clinical diagnosis of congenital heart disease
•Undergoing heart surgery with cardiopulmonary bypass

排除标准

•Pulmonary arterial hypertension
•Sevoflurane allergy

研究组 & 干预措施

Sevoflurane

Experimental

Sevoflurane will be used as a narcotic drug in one group during cardiac surgery.

干预措施: Sevoflurane (Drug)

结局指标

主要结局

Concentration of S100β protein

时间窗: 5 minutes after tracheal intubation; immediately after cardiopulmonary bypass; immediately after operation; 12 hours, 24 hours postoperative

The concentration of S100β protein was performed using the electrochemiluminescence immunoassay.(Blood samples from patients were drawn from central intravenous.)

次要结局

Level of regional cerebral oxygen saturation(rScO2)(5 minutes after tracheal intubation; immediately after cardiopulmonary bypass; immediately after operation; 12 hours, 24 hours postoperative)

研究者

发起方

Jun Ma

申办方类型

Other

责任方

Sponsor Investigator

主要研究者

Jun Ma

The Chief of Anesthesiology Department

Beijing Anzhen Hospital

研究点 (1)

Loading locations...

相似试验

已完成

不适用

Study of the cerebral effects of sevoflurane, propofol and remifentanil as measured by the spontaneous electro-encephalogramgezonde vrijwilligers die onder anesthesie worden gebrachtAnesthesia administrationAnesthesia monitoring10009720

NL-OMON40298MASIMO36

进行中（未招募）

不适用

improving Information Extraction from EEG on cerebral anesthetic drug effectsWe will include 36 healthy volunteers (American Society of Anesthesiologists 1) stratified to age groups and randomized to different sequence of anesthesia regimen.

EUCTR2013-000119-25-NLmasimo36

已完成

4 期

The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic ArteriesSevoflurane Anesthesia

NCT02054143University of Debrecen24

尚未招募

不适用

The Sevoflurane study, understanding the effects of Sevoflurane to improve safety and outcome of cardiac surgery.

NL-OMON20447none40

已完成

4 期

Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEGMiddle Aged PatientsGeneral Anesthesia

NCT01705743Huazhong University of Science and Technology76