Rocuronium vs Cis-atracurium: Do Rocuronium Still 'ROCKS' In Coronary Artery Bypass Grafting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 289
- 试验地点
- 1
- 主要终点
- Incidence of postoperative pulmonary complication
研究概览
简要总结
The current trend in most cardiac surgeries was to use rocuronium as it provides faster recovery in train-of-four ratio compared to other aminosteroid non-depolarising neuromuscular blocker. However, as most cardiac centres' standard of care does not perform any neuromuscular monitoring nor antagonism of neuromuscular blockade effect, residual neuromuscular blockade could potentially be the key to delayed extubation. As such, Cis-atracurium's organ-independent Hofmann elimination could be in favour.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients that undergo general anaesthesia for CABG surgery requiring neuromuscular blockade of either rocuronium or cis-atracurium
排除标准
- •Recent history of pulmonary infection four weeks before surgery
- •Exposed to both neuromuscular blockade within 24 hours perioperatively
- •Patients intubated or on tracheostomies pre-operatively
- •Any missing or incomplete data
研究组 & 干预措施
Rocuronium
Rocuronium 1mg/kg to be given at induction of anaesthesia and another 1mg/kg would be given when the patient is on hypothermic cardiopulmonary bypass
干预措施: Rocuronium Bromide 10 MG/ML (Drug)
Cis-atracurium
Cis-atracurium 0.2mg/kg to be given at induction of anaesthesia and another 0.2mg/kg would be given when the patient is on hypothermic cardiopulmonary bypass
干预措施: Nimbex 10 MG in 5 ML Injection (Drug)
结局指标
主要结局
Incidence of postoperative pulmonary complication
时间窗: 6 months
Which neuromuscular relaxant is associated with lesser postoperative pulmonary complication
次要结局
- Ventilation hours in ICU(6 months)
- Requirements for Non-invasive ventilation(6 months)
- Incidence of postoperative atrial fibrillation(6 months)
研究者
SONG LIN LOW
Dr
Institut Jantung Negara