An implementation-effectiveness trial investigating feasibility, safety and efficacy of Best pRacticE guideline cAre physioTHErapy with addition of protocolised ventilator hyperinflation on patient-important outcomes for critically ill adults intUbated and ventilated with Pneumonia. (BREATHE UP)

South Metropolitan Health Service0 个研究点目标入组 225 人开始时间: 2024年9月18日最近更新: 2024年9月30日

适应症

试验速览

暂无简介。

•ICU admission with diagnosis of pneumonia made by a medical practitioner.•Aged equal to or greater than 18 years•Intubated and mechanically ventilated, expected to remain so for equal to or greater than 24 hours, not planned for extubation this calendar day.•Evidence of consolidation or volume loss on CXR, CT scan or lung ultrasound.•Evidence of sputum on clinical assessment by a physiotherapist, e.g. auscultation, palpation, endotracheal suction, waveform analysis.

•Death imminent or the treating clinician believes that death during this hospital admission is inevitable.•Treating clinician believes that trial participation is not in the best interests of the patient.•Receiving invasive mechanical ventilation for greater than 5 days•Peak airway pressure greater than 35cmH20 consistently for greater than 2 hours •Progression to severe ARDS according to Berlin Criteria [32]•Requirement for extracorporeal membrane oxygenation•Severe bronchospasm•Undrained pneumothorax or bronchopleural fistula•Pulmonary haemorrhage•Lung transplantation or recent lung surgery with bronchial resection•Unable to communicate in English•Pregnancy•Underlying neurological or myopathic condition•Documented cognitive impairment•BMI greater than 35•Hospitalisation for greater than 7 days prior to ICU•Presence of active cancer or active use of chemotherapeutic agents or neutropenia•Unlikely to be available for 3-month follow-up (resides overseas)

-Disability[WHODAS 2.0 Day 90 post randomisation.]

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