Impact of Preterm Single Donor Milk on Enteral Feeding in Very Low Birth Weight Infants
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infant, Premature, Diseases
- Sponsor
- Medical University of Vienna
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Time to full enteral feeding
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Human milk is the best source of enteral nutrition for the preterm infant. However during the infants first hours and days of life breastmilk from the own mother is usually not available. Until May 2012 the practice in the Neonatal Division of the Department of Pediatrics /Medical University Vienna was to start with formula feedings within the first 6 hours of life of a premature infant and switch over to breastmilk as soon it was available. In June 2012 the investigators changed this feeding regimen and started to use single donor milk of mothers of preterm infants for the first hours and days of the preterm infants life. In a prospective observational study the investigators evaluated the impact of single donor milk from preterm infants on time to full enteral feedings, gastrointestinal tolerance and NEC incidence in preterm infants with a birthweight below 1500 grams and a gestational below 32 weeks. Data will be compared with a historical control group starting with preterm formula as source of enteral nutrition. The investigators hypothesize that starting enteral nutrition with single donor milk of mothers from preterm infants with shorten time to full enteral feedings.
Investigators
Nadja Haiden,MD
MD, Assoc. Prof.
Medical University of Vienna
Eligibility Criteria
Inclusion Criteria
- •very low birth weight infants with a birthweight \<1500g
- •Gestational Age \<32 weeks
- •Informed consent
Exclusion Criteria
- •major congenital malformations
- •systemic metabolic diseases
- •short bowl syndrome
- •gastrointestinal abnormalities
- •when preterm infant was transferred or discharged
Outcomes
Primary Outcomes
Time to full enteral feeding
Time Frame: birth up to 40 weeks of gestation
Full enteral feedings are defined as an enteral inane of 135-145ml/kg/d
Secondary Outcomes
- Frequency of stool(birth until 14th day of life)
- culture positive sepsis(birth to 40th week of gestation)
- necrotizing enterocolitis(birth to 40 weeks of gestation)
- Gastric residuals(birth to 7th day of life)