Prognosis Value of Transient Elastography and Non-invasive Markers of Fibrosis in Patients With Chronic Liver Disease. A Prospective Follow-up of 4,935 Person-years
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Liver Fibrosis
- Sponsor
- Association HGE CHU Bordeaux Sud
- Enrollment
- 1830
- Locations
- 1
- Primary Endpoint
- Overall survival
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of this prospective study was to compare the 5-year prognostic value of transient elastography (TE), FibroTest (FT), APRI , FIB-4, Lok, and Child-Pugh scores for predicting survival and complications of cirrhosis in patients with chronic liver diseases.
Detailed Description
A total of 1616 patients with chronic hepatitis C was included. At 5 years, 79 patients were dead (39 liver-related deaths) and 16 patients had liver transplantation. Overall survival was 91.7% and survival without liver-related death 94.4%. Survival was significantly decreased in patients diagnosed with severe fibrosis, whatever the non-invasive method used. All these methods were able to predict a shorter survival in this large population. Patients had their prognosis decreased as liver stiffness increased. By multivariate analysis, only FibroTest \> 0.74 (OR 4.41, 95%CI 1.62-12.01, p=0.004) was associated with overall survival, and liver stiffness \> 9.5 kPa (OR 4.71, 95%CI 1.06-21.01, p=0.04) associated with liver-related death.
Investigators
de Ledinghen
Professor
Association HGE CHU Bordeaux Sud
Eligibility Criteria
Inclusion Criteria
- •chronic hepatitis C
- •chronic hepatitis B
- •alcoholic liver disease
- •non alcoholic steatohepatitis
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Overall survival
Time Frame: 3 months
Secondary Outcomes
- Survival without liver complications(3 months)
- Survival without liver transplantation(3 months)