Urethral Stricture: A Comparison Between Jugal or Labial Graft Urethroplasty
- Conditions
- Urethral Stricture
- Interventions
- Procedure: Jugal GraftProcedure: Labial Graft
- Registration Number
- NCT03973619
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Brief Summary
Buccal mucosa urethroplasty is a current fashion in urethral stricture management. In our university centre (Hospital de Clínicas de Porto Alegre) is a common surgical treatment choice. This paper aims to evaluate the success rate of this treatment after randomized choice between labial and jugal (inner cheek) grafts during the past two years.
- Detailed Description
Free dorsal graft urethroplasty, first described by Barbagli et al, has been shown better results than ventral grafts. Fixed grafts on the corpora cavernosa results in a better mechanical support and vascular supply, with less chance to complications such as pseudodiverticula and sacculations either a better urethral phisiology.
This study aims to evaluate the current surgical management in our centre: buccal mucosa graft urethroplasty with jugal or labial replacement, comparing their group success rate and complications between the groups in patients led to surgery from October 2016 to June 2018.
Prospective analysis from urethral stricture surgical HCPA patient data by dorsal buccal mucosa graft urethroplasty. The graft choice were done by a software. Longer stricture with transoperative need for the two grafts use were excluded. Success rate were measured with a no stricture de novo or absence of complications in a six month interval.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 77
- Urethral Stricture Diagnosis
- Indication for buccal mucosa graft urethroplasty
- Accept the Informed Consent Term (patient or responsible)
- Severe urethral stricture which a two-staged procedure are required
- Long strictures which need a both types of buccal mucosa graft due its length.
- Refuse to ICT for the patient ou it responsible
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Jugal Jugal Graft Patients who received a jugal (inner cheek) graft as replacement of urethral tissue Labial Labial Graft Patients who received a labial graft as replacement of urethral tissue
- Primary Outcome Measures
Name Time Method Labial Group Success Rate 6 months Absence of surgical intervention after prior surgery on patients who received a labial graft.
Latex Catheter Success Rate 6 months Absence of surgical intervention on patients who used a latex catheter indwelling after prior surgery.
Jugal Group Success Rate 6 months Absence of surgical intervention after prior surgery on patients who received a inner cheek graft.
Silicon Catheter Success Rate 6 months Absence of surgical intervention on patients who used a silicon catheter indwelling after prior surgery.
Overall Success Rate 6 months Absence of surgical intervention after prior surgery
- Secondary Outcome Measures
Name Time Method Stricture Size 24 months Evaluation of the stricture length (cm) on patients included on Labial and Jugal Groups
Stricture Etiology 24 months Evaluation of the etiology of the stricture (trauma, other, infectious) on patients included on Labial and Jugal Groups
Stricture Localization 24 months Evaluation of the stricture localization (penile, bulbar/bulbomembranous or combined) on patients included on Labial and Jugal Groups
Demographic Data 24 months Evaluation of the demographic data relationship with the results (age, cystotomy, cystostomy time, tobacco use, diabetes, balanitis xerotica, UTI infection, serum creatin levels) included on Labial and Jugal groups