An Assessment of Bone Augmentation in Post-Extraction Sockets

Not Applicable

Completed

Interventions: Procedure: Atraumatic Teeth Extraction/Grafted Extraction Sockets
Procedure: AtraumaticTeeth Extraction

Brief Summary: When a tooth is extracted the ridge of bone that held the tooth in place begins to heal and over time new bone grows to fill the empty space left by the missing tooth. Sometimes this process works very well and new bone grows to completely fill the socket, at other times new bone fails to fill in the space completely and patients are left with uneven bone-fill.

Grafted extraction sockets may fill with bone faster and more evenly than those without grafts, allowing the dentist to have greater control over the healing process and to repair the area with dental implants in a shorter period of time.

This study will help determine if grafting an extraction socket, with or without enriching the graft material, is an added benefit when compared to allowing the socket to heal naturally.

The study will also assess how well two different dental implant designs used to restore the area will function over time.

Detailed Description: Tooth extraction is often associated with resorption of the alveolar ridge height and width and with compromised soft tissue contours. A variety of methods have been proposed to overcome varied patterns of post-extraction healing.

An increasingly common practice combines skilled surgical technique with post-extraction site grafting utilizing both natural and synthetic bone-graft materials. These procedures are thought to retard resorption of the socket volume while lending some control over bone-fill - thereby preserving the integrity of the alveolar ridge for future reconstruction with dental implants.

Limited evidence-based data exist to support a variety of bone-graft materials including grafts enriched with autologous platelet-rich plasma(PRP)and grafts enriched with recombinant human platelet-derived growth factors(PDGF). Despite emerging clinical acceptance the most efficacious intervention remains undetermined.

In an effort to establish clinical evidence, this study will assess the efficacy of ridge preservation using three different bone grafting applications in post-extraction sockets compared to extraction alone.

The study will also asses longitudinal success of restoring the study sites with dental implants. Two innovative dental implant designs will be used in the study; an implant with a resorbable blast textured(RBT)surface and an implant with a laser thread-textured (LTT)surface.

Recruitment & Eligibility

Inclusion Criteria

Needed extraction of Maxillary and/or Mandibular Incisors and/or Pre-molar teeth

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
4 FDBA/TCP + PDGF	Atraumatic Teeth Extraction/Grafted Extraction Sockets	-
2- FDBA/TCP	Atraumatic Teeth Extraction/Grafted Extraction Sockets	-
3 FDBA/TCP+PRP	Atraumatic Teeth Extraction/Grafted Extraction Sockets	-
1	AtraumaticTeeth Extraction	Teeth extraction followed by natural healing

Primary Outcome Measures

Name	Time	Method
Bone-fill in Grafted Post-extraction Sockets Versus Bone-fill in Non-grafted Post-extraction Sockets	2 months	New bone formation in grafted extraction sockets to that of sites healed after 8 weeks of post-extraction.

Secondary Outcome Measures