Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients

Completed

• Conditions: Cardiomyopathies
• Interventions: Diagnostic Test: Global Longitudinal Strain

• Registration Number: NCT04358952
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown. Epidemiological studies report biological myocardial involvement in 10 to 25% of cases. The objective of this study is to cardiac phenotype using comprehensive cardiac imaging tools of patients infected with Covid 19 in order to explore the functional impact of the infection on the myocardium.

Detailed Description

A large population of Covid 19 infected patients of different ages and severity levels will be explored by transthoracic echocardiography with measurement of myocardial functional parameters such as ejection fraction, longitudinal strain and relaxation parameters and will be compared to an uninfected population paired for age and sex.

Patients with biological myocardial involvement will be followed to determine the evolution of their myocardial functional parameters during the course of the infection.

Study Timeline

• Study Start: 2020-04-04
• Study First Submitted: 2020-04-09
• Study First Submitted QC: 2020-04-20
• Study First Posted: 2020-04-24
• Primary Completion: 2021-04-02
• Study Completion: 2021-04-02
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-28
• Last Update Posted: 2021-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 122

Inclusion Criteria

• Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR

Exclusion Criteria

• Underage patients. Patients refusing to participate in research. Patients with a history of heart disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COVID + patients	Global Longitudinal Strain	Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR

Primary Outcome Measures

Name	Time	Method
Left ventricular function	Day 7	Left ventricular function evaluated by global longitudinal strain

Secondary Outcome Measures

Name	Time	Method
inflammatory biological parameters	Day 0	Cytokine rate

Trial Locations

Locations (1)

UHToulouse; 🇫🇷 Toulouse, France