Contribution of [18F]DPA-714 PET for Grading and Exploration of the Inflammatory Microenvironment of Glioma, a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Diagnostic performances of [18F]DPA-714 PET for glioma grading obtained by stereotactic biopsies of glioma
研究概览
简要总结
The 18-kDa translocator protein (TSPO) is a mitochondrial protein that is weakly expressed in the healthy brain. However, there is an increase in the expression of TSPO in glial tumors. It is even associated with a higher malignancy and a shorter survival of patients. Among the different TSPO ligands, the most commonly used tracers in PET imaging are [18F]DPA-714 and 18F-GE180. We hypothesize that [18F]DPA-714 PET could improve the current performance for tumor grade definition in vivo, which is a major issue for the therapeutic management of gliomas.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age greater than or equal to 18 years
- •Suspicion of an operable diffuse glioma
- •Written informed consent (signed)
- •Affiliated or beneficiary of a social security plan
排除标准
- •Suspicion of grade I glioma
- •Surgical urgency (less than 8 days between the suspected diagnosis and surgery)
- •Pregnant or breastfeeding woman
- •Persons deprived of liberty or under guardianship
- •Impossibility to undergo the medical follow-up of the trial for geographical, social or psychological reasons
研究组 & 干预措施
[18F]DPA-714 PET
干预措施: [18F]DPA-714 (Drug)
结局指标
主要结局
Diagnostic performances of [18F]DPA-714 PET for glioma grading obtained by stereotactic biopsies of glioma
时间窗: [18F]DPA-714 PET performed up to 30 days before brain surgery
Sensitivity and specificity of \[18F\]DPA-714 PET using anatomopathological assessment of biopsies as gold standard
次要结局
- Comparison of [18F]DPA-714 PET quantitative parameters with anatomopathological assessment of the surgery specimen([18F]DPA-714 PET performed up to 30 days before brain surgery)
- Comparison of [18F]DPA-714 PET quantitative parameters with tumor microenvironment([18F]DPA-714 PET performed up to 30 days before brain surgery)