Effects of telephone counseling intervention by pharmacist on medication adherence for patients starting treatment: A cluster randomized controlled trial.
Recruiting
- Conditions
- compliance, adherence, persistence, statins, bisphosphonates, antidepressants, RAS-inhibitors, BMQ, beliefs, SIMS
- Registration Number
- NL-OMON24491
- Lead Sponsor
- trecht Institute for Pharmaceutical Sciences
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 4400
Inclusion Criteria
1. Age over 18 years;
2. In posession of telephone;
Exclusion Criteria
1. Life expectancy of less than 6 months;
2. Receiving medication weekly (e.g. automated dispensing);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcomes measured are taking-compliance measured over 365 days and the occurrence of complete discontinuation. Taking-compliance will be based on refill data and will be expressed as Proportion of days covered over a period of 365 days (12 months PDC). Differences in median proportion of days covered will be tested using the non-parametric Mann Whitney U test and the percentage of adherent patients between groups will be analyzed with χ2-test. Complete discontinuation will be defined as exceeding the permissible gap of 90 days within the one year observation period. Cox-proportional hazards will be used to compare discontinuation between intervention and control patients.
- Secondary Outcome Measures
Name Time Method The occurence of early discontinuation after 3 and 6 months. Score on the Beliefs about Medicines Questionnaire (BMQ) and Satisfaction with Information about Medicines Scale (SIMS) after 3 months.