Renal biomarkers in hantavirus infectio

Recruiting

Conditions: N17.9
A98.5
Acute renal failure, unspecified
Haemorrhagic fever with renal syndrome

Registration Number: DRKS00013884

Lead Sponsor: ierenzentrum Heidelberg, Universitätsklinikum Heidelberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 300

Inclusion Criteria

Being able to give consent
- Written consent form of study participants
- Suspicion of Hantavirus infection or proven Hantavirus infection
- Women and men at the age of 18-99 years

Exclusion Criteria

- Non-fulfillment of inclusion criteria
- Refusal of participation

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Evaluation of renal damage biomarkers concerning their potential to predict a severe disease course during Hantavirus-associated acute kidney injury (AKI). (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)<br>- Differentiation of the biomarkers and evaluation of their correlation with laboratory values and cellular substructures. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)

Secondary Outcome Measures

Name	Time	Method
- Comparison of biomarkers with already established, intrinsic markers of renal function and evaluation of their correlation with length of inpatient stay and need for renal replacement therapy. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)<br>- Analysis of potential (clinical) risk factors predisposing for a Hantavirus infection and severe disease courses.<br>- Analysis of different RNA-/DNA-expression patterns/methylation patterns in urine and blood and their correlation with AKI course, multifactorial AKI and hanta virus pathogenesis. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)