Comparison of the effect of oral sotalol and oral metoprolol succinate in the prevention of atrial fibrillation after coronary artery bypass surgery.
- Conditions
- Condition 1: coronary artery bypass graft. Condition 2: Atrial fibrillation and flutter.Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectorisAtrial fibrillation and flutterI25.7
- Registration Number
- IRCT20231123060154N1
- Lead Sponsor
- Qazvin University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 188
Patients who are candidates for CABG
Previous history of atrial fibrillation
Having a permanent pacemaker
Any definite or probable evidence of having any type of ventricular or supraventricular arrhythmia
Moderate and severe LV enlargement
Moderate and severe valvular heart disease
acute MI
Prolonged QT
Patients with severe renal impairment and ESRD
Asthma and bronchospasm
Patients with hemodynamic disorders and low blood pressure
Patients who are taking drugs that interact with sotalol will be excluded from the study if it is not possible to stop the drug. These drugs include: All QT prolonging drugs including: Amiodarone, Amisulpride, Azithromycin, Carbetocin, Ceritinib, Chloroquine, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clozapine, Dabrafenib, Dasatinib, Domperidone, Doxepine-containing products, Droperidol, Encorafenib, Entrectinib ) otinib, Olanzapine, Ondansetron, Osimertinib, Oxytocin, Pacritinib, Pazopanib, Pentamidine, Pilsicainide, Pimozide, Piperaquine, Probucul, Propafenone, Propofol, Quetiapine, Ribociclib, risperidone, Sertindole, Sparfloxacin, Sunitinib, Terbutaline, Thioridazine, Toremifene, Vemurafenib : Alfuzocin, Alpha1- Blockers, Amifostine, Phenothiazines, Barbiturates, Benperidol, Levodpa- Containing products, Lormetazepam, Methoxyflurane, Molsidomine, Naftopidil, Nicergoline, Nicorandil, Nifedipine, Nitroprusside, Obinutuzumab, Pentoxyfilline, Pholcodine, Phosphodiesterase 5 inhibitors, Prostacyclin, Quinagolide, Reserpine: Acetylcholinesterase inhibitors, Ceritinib, Dipyridamole, Etilefrine, Ivabradine, Lacosamide, Midodrine, Ozanimod, Ponesimod, Siponimod, Blood sugar lowering drugs: Insulins, Sulfonylureas, Antidiabetic agents
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Occurrence of atrial fibrillation. Timepoint: Patients are continuously cardiac monitored for atrial fibrillation. Method of measurement: ECG.
- Secondary Outcome Measures
Name Time Method