Diet history in PCOD

Not yet recruiting

Conditions: Polycystic ovarian syndrome,

Registration Number: CTRI/2019/11/022113

Lead Sponsor: ICMR

Brief Summary: Polycystic ovary syndrome (PCOS) is a multifactorial disorder and different genetic, hormonal, and environmental etiology can contribute to its pathology (1). The diagnosis of PCOS in women is usually according to Rotterdam criteria, which is based on having at least two of three characteristics of oligo-ovulation/ anovulation, hyperandrogenism and polycystic ovaries using ultrasonographic images (2). Many hypotheses about the pathophysiology of PCOS that have been explained so far, include: resistant to rupture of follicles due to shell thickness, ovarian hyperandrogenism, luteinizing hormone (LH) hypersecretion, hyperinsulinemia, and impaired ovarian follicular development due to increased follicular development blocker paracrine factors, such as anti-MÃ¼llerian hormone (AMH) (3). The causes of any of these abnormalities may be due to genetic factors that are commonly found in homozygous twins studies or due to metabolic, hormonal, nutritional or even toxic changes during embryonic development and in early stages of female gonad differentiation (4). But still, the exact origin of each abnormality is unclear. Several observations show that the interaction of several genetic factors and environmental factors are necessary for PCOS development.

References

1. De Leo V, Musacchio M, Cappelli V, Massaro M, Morgante G,Petraglia F. Genetic, hormonal and metabolic aspects of PCOS:an update. Reprod Biol Endocrinol 2016;14:38-54.

2. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnosticcriteria and long-term health risks related to polycystic ovarysyndrome (PCOS). Hum Reprod 2004;19:41-47.

3. Fenichel P, Rougier C, Hieronimus S, Chevalier N. Whichorigin for polycystic ovaries syndrome: Genetic, environmentalor both? Ann Endocrinol 2017;78:176-185.

4. Deligeoroglou E, Kouskouti C, Christopoulos P. The role ofgenes in the polycystic ovary syndrome: predisposition andmechanisms. Gynecol Endocrinol 2009;25:603-609.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Female

Target Recruitment: 50

Inclusion Criteria

Females diagnosed with PCOS using rotterdam criteria.

Exclusion Criteria

Not willing to participate.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Etiological clue	after analysis of results

Secondary Outcome Measures

Name	Time	Method
Clinical profile	by the end of the trial
Diet history and correlation with PCOS	after analysis of results
lifestyle and risk of PCOS	after analysis of results

Trial Locations

Locations (1): GSL Medical College
🇮🇳
Godavari, ANDHRA PRADESH, India
GSL Medical College
🇮🇳Godavari, ANDHRA PRADESH, India
Murali Krishna K
Principal investigator
9948860777
murali8573@gmail.com