Comparison of two different doses of intravenous ketamine (intravenous anesthetic agent) added to intravenous dexmedetomidine (sedative) for awake fibre optic nasotracheal intubation

Completed

• Conditions: Medical and Surgical, (2) ICD-10 Condition: 8||Other Procedures,

• Registration Number: CTRI/2021/11/038037
• Lead Sponsor: Goa Medical College and Hospital

Brief Summary

The purpose of this study to compare different doses of intravenous ketamine (20mg followed by infusion of 1mg/kg/hour vs 40mg bolus dose) added to intravenous dexmeditomidine for smooth and with less hemodynamic disturbances for awake fibreoptic nasotracheal intubation .

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-22
• Study Completion: 2021-11-23
• Last Update Posted: 2024-06-09

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with predicted airway posted for surgery under general anaesthesia ASA grade I and II.

Exclusion Criteria

1.Uncooperative patient/inability to communicate effectively 2.Pregnant women or patients requiring rapid sequence induction 3.Cardiopulmonary disease, heart rate (HR) <50 beats/min or any type of atrioventricular block on the electrocardiogram 4.Allergy to the drugs involved in the study 5.History of drug or alcohol abuse, and patients on long-term opioids or sedative medication 6.Contraindication for nasal intubation 7.Patients of difficult airway with impending airway obstruction.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess time taken for intubation on administration of two different doses of intravenous ketamine added to intravenous dexmedetomidine for awake fibre optic nasotracheal intubation	To assess time taken for intubation on administration of two different doses of intravenous ketamine added to intravenous dexmedetomidine for awake fibre optic nasotracheal intubation from the point of introduction of the bronchoscope into the nares of the patient until securing the nasotracheal tube at the level of carina (which will be confirmed by direct visualization of trachea and carina using bronchoscope and capnography to exclude esophageal intubation.

Secondary Outcome Measures

Name	Time	Method
Assessing variation in following parameters ie heart rate, Systolic blood pressure, Diastolic blood pressure, Mean Arterial pressure, Oxygen Saturation during the procedure of awake fibreoptic bronchoscope guided nasotracheal intubation.

Trial Locations

Locations (1)

Goa Medical College and Hospital, Operation Theatre ,(Lower and Upper OT); 🇮🇳 Goa, GOA, India

Goa Medical College and Hospital, Operation Theatre ,(Lower and Upper OT)

🇮🇳Goa, GOA, India

Dr Pratiksha Sutar

Principal investigator

7507402597

pratiksha_sutar@ymail.com