Lime Powder Regimen (LPR) for Prevention of Renal Stone Recurrence
- Registration Number
- NCT03258190
- Lead Sponsor
- Chulalongkorn University
- Brief Summary
Lime powder regimen (LPR) is a lime-derived composition enriches with citrate/citric acid and potassium. LPR was invented to treat the renal stone patients with high risk of stone recurrence after stone removal. LPR should have equal or higher efficacy and lower adverse effect than current standard medicine.
- Detailed Description
Lime powder regimen (LPR) is a mixture of lime-derive component with adjuvants containing high concentration of citrate, and moderate amount of potassium, magnesium and antioxidants. LPR was tested and verified to be very less toxic in cell culture and animal models. The clinical trial phase II showed that LPR reduced urinary metabolic abnormalities that enhance stone formation, such as hypocitraturia, hypokaliuria and acidified urine. Adverse effect of LPR was very low.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 137
- Renal stone patients who were identified and stone was removed by surgical method.
- Chronic kidney disease, chronic liver disease, history of coronary artery disease, or person who takes any medication that alters urinary metabolic profiles
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Lime Powder Regimen Participants were asked to take Placebo twice a day for 6 months Lime Powder Regimen Lime Powder Regimen Participants were asked to take LPR twice a day for 6 months
- Primary Outcome Measures
Name Time Method Renal stone recurrence 6 months The stone recurrence after surgical removal of stone that can be detected by CT scan
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chulalongkorn University
🇹🇭Bangkok, Thailand