Short Term Refractive and Ocular Parameter Changes After Topical Atropine

Not Applicable

Completed

• Conditions: Myopia, Left Eye
• Interventions: Drug: 0.125% Atropine

• Registration Number: NCT03839888
• Lead Sponsor: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

Brief Summary

In order we had designed a prospective clinical trial. Spherical equivalent refractive error (SER), axial length (AL), mean keratometric value (Mean-K), anterior chamber depth (ACD), and intraocular pressure (IOP) were measured at baseline and one week after topical use of 0.125% atropine. Postcycloplegic changes of refractive error and ocular parameters were evaluated, and their correlations were analyzed with multiple linear regression models.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2015-12-31
• Study Completion: 2015-12-31
• Status Verified: 2019-02
• Study First Submitted: 2019-02-10
• Study First Submitted QC: 2019-02-11
• Last Update Submitted: 2019-02-11
• Study First Posted: 2019-02-15
• Last Update Posted: 2019-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• Patients who had an SER of -0.5 diopters or less in their eyes.

Exclusion Criteria

• Patients who had already been undergoing cycloplegic treatment for myopia before.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
0.125% atropine group	0.125% Atropine	patients used the 0.125 % atropine eyedrop every night before sleep for 7 days

Primary Outcome Measures

Name	Time	Method
SER	change from SER at 7 days	Spherical equivalent refractive error

Secondary Outcome Measures

Name	Time	Method
AL	change from AL at 7 days	Axial length
ACD	change from ACD at 7 days	anterior chamber depth
IOP	change from IOP at 7 days	intraocular pressure