Effect of Berberine on Hormonal and Metabolic Features in Obese Women With Polycystic Ovary Syndrome (PCOS)
- Registration Number
- NCT01138930
- Lead Sponsor
- Heilongjiang University of Chinese Medicine
- Brief Summary
Berberine has showed effective in lowering blood sugar levels in db/db mice and anti-dyslipidemia in human.Studies on the effect of berberine on metabolic and hormonal features of women with polycystic ovary syndrome (PCOS) are lacking.The objective of this study is to examine the effect of Berberine metabolic and hormonal parameters and insulin resistance in obese patients with PCOS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 120
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - Berberine Berberine -
- Primary Outcome Measures
Name Time Method Whole body insulin action 3 months Glucose Disposal Rate measured by hyperinsulinemic euglycemic clamp
- Secondary Outcome Measures
Name Time Method Oral glucose tolerance test (OGTT) 3 months Ovarian androgen biosynthesis 3 months Hormonal profile 3 months Fasting lipid metabolic profile 3 months Renal and liver function tests 3 months Adverse events 3 months 6) Weight, waist/hip circumference, blood pressure, F-G score and acne before and after treatment. Three months
Trial Locations
- Locations (4)
First Affliated Hospital of Harbin Medical University
🇨🇳Harbin, Heilongjiang, China
Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, Guangdong, China
Forth Affiliated Hospital of Harbin Medcal University
🇨🇳Harbin, Heilongjiang, China
Department of Obstetrics and Gynecology,First Affliated Hospital,Heilongjiang University of Chinese Medicine .
🇨🇳Harbin, Heilongjiang, China