NCT01138930Unknown不适用
Effect of Berberine on Hormonal and Metabolic Features in Obese Women With PCOS
Heilongjiang University of Chinese Medicine4 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2010年6月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 4
- 主要终点
- Whole body insulin action
研究概览
简要总结
Berberine has showed effective in lowering blood sugar levels in db/db mice and anti-dyslipidemia in human.Studies on the effect of berberine on metabolic and hormonal features of women with polycystic ovary syndrome (PCOS) are lacking.The objective of this study is to examine the effect of Berberine metabolic and hormonal parameters and insulin resistance in obese patients with PCOS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Berberine
Experimental
干预措施: Berberine (Drug)
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Whole body insulin action
时间窗: 3 months
Glucose Disposal Rate measured by hyperinsulinemic euglycemic clamp
次要结局
- Oral glucose tolerance test (OGTT)(3 months)
- Ovarian androgen biosynthesis(3 months)
- Hormonal profile(3 months)
- Fasting lipid metabolic profile(3 months)
- Renal and liver function tests(3 months)
- Adverse events(3 months)
- 6) Weight, waist/hip circumference, blood pressure, F-G score and acne before and after treatment.(Three months)
研究者
Xiaoke Wu
Professor and Chairman Dept Obs & Gyn, First Affiliated Hospital
Heilongjiang University of Chinese Medicine
研究点 (4)
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