Study of Prediction of Opioid Analgesic
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Surgery
- Sponsor
- Huazhong University of Science and Technology
- Enrollment
- 131
- Locations
- 1
- Primary Endpoint
- Rangeability of pressure pain threshold
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
This study aimed to find a quick and timely way to predict the individual variation of efficacy of opioid analgesic during the operation and postoperative analgesia in Chinese patients undergoing elective surgeries. Methods: female patients receiving elective surgery under general anesthesia were recruited into this study. At the time of routine intravenous anesthetic induction we observe the efficacy of opioid analgesic including analgesic effect, effects on Narcotrend index, sedative effect, effects on respiratory system, and aslo effects on cardiovascular system. Then we record the consumption of of opioid analgesic during the operation and postoperative analgesia. Also we record the side effect of the opioid analgesic.
Detailed Description
Patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.
Investigators
Xianwei Zhang
Professor, MD.
Huazhong University of Science and Technology
Eligibility Criteria
Inclusion Criteria
- •Aged 20-65 years
- •Anesthesiologists (ASA) physical status I or II;
- •Within ±20% of ideal body weight;
- •Agreed to participate the research
Exclusion Criteria
- •History of chronic pain;
- •Psychiatric diseases;
- •Diabetes mellitus;
- •Severe cardiovascular diseases;
- •Kidney or liver diseases;
- •Alcohol or drug abuse (according to the criteria of DSM-IV);
- •Pregnancy or at lactation period;
- •Disagree to participate to the research
Outcomes
Primary Outcomes
Rangeability of pressure pain threshold
Time Frame: 8 months
According to the measurement of pressure pain threshold before and after intravenous injection of opioid analgesics
Secondary Outcomes
- Rangeability of Narcotrend index(8 months)
- Rangeability of Ramsay Sedation Scale(8 months)
- Rangeability of respiratory frequency(8 months)