Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis

Phase 4

• Conditions: Renal Failure, End Stage; Peritoneal Dialysis

• Registration Number: NCT00291863
• Lead Sponsor: Federal University of São Paulo

Brief Summary

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

Detailed Description

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

Study Timeline

• Status Verified: 2006-02
• Study Start: 2006-02
• Study Completion: 2006-02
• Study First Submitted: 2006-02-14
• Study First Submitted QC: 2006-02-14
• Study First Posted: 2006-02-15
• Last Update Submitted: 2006-02-15
• Last Update Posted: 2006-02-16

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• end stage renal failure
• peritoneal dialysis
• LDL cholesterol > 100mg/dL
• > 18 years and < 80 years

Exclusion Criteria

• using statin or nitrate
• liver disease
• diabetes mellitus

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
endothelial venodilation

Secondary Outcome Measures

Name	Time	Method
Inflammation markers (C-reactive protein, IL-6, TNF)
Lipoproteins
Oxidative stress

Trial Locations

Locations (1)

São Lucas Hospital; 🇧🇷 Porto Alegre, Rio Grande do Sul, Brazil