Measuring differences in breathing patterns between asthma patients and healthy subjects during physical exercise and the effect on the level of dyspnoea using respiratory inductance plethysmography

Completed

Conditions: asthma
10006436
Bronchial asthma

Registration Number: NL-OMON50858

Lead Sponsor: Medisch Spectrum Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 108

Inclusion Criteria

Asthma group:
- Confirmed asthma diagnosis by a health professional
- Patient using inhalaled corticosteroids
- Normal lung function under treatment (FEV1>80% predicted post salbutamol)
- Age 18-60

Healthy groep:
- No pulmonary disease
- No usage of lung related medication
- Age 18-60

Exclusion Criteria

- Asthma exacerbation within 6 week before inclusion (asthma group only)
- More than 10 pack-years
- Pulmonary disease other than asthma
- Neurological or muscular disorder
- Meets one of the contra-indications mentioned in the cycling ergometry
protocol from MST
- Has been tested postively for covid-19 in the past 3 months or has not fully
recovered from an earlier covid-19 infection

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the breathing pattern. The breathing pattern is<br /><br>defined as the relative contribution of the breathing frequency (Bf), tidal<br /><br>volume (Vt), abdominal breathing and thoracic breathing to the respiratory<br /><br>minute volume and how these change during physical exercise. These parameters<br /><br>will be compared between all subjects and cluster analysis will be performed in<br /><br>order to define different breathing patterns. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary goal of the study consist of the investigation whether certain<br /><br>breathing patterns can lead to EID. The level of dyspnoea will be objectified<br /><br>using BORG and visual analog scale (VAS) scores.</p><br>