The Beta Cell Responsiveness to Glucose-dependent Insulinotropic Polypeptide (GIP) With and Without Sulfonylurea in Patients With Type 2 Diabetes
Phase 2
Completed
- Conditions
- Diabetes Mellitus, Type 2
- Registration Number
- NCT00321321
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Brief Summary
The investigators hypothesize that the impaired insulinotropic effect of the incretin hormone GIP may be due to inadequate sensitization and ATP induced closure of beta cell K-ATP channels. By closing the channels through the use of sulfonylurea (SU) we hope to restore the insulinotropic effect of GIP.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- Type 2 diabetes mellitus diagnosed according to WHO criteria
- Diet and/or metformin treatment
- HbA1c > 7,0% for metformin treated patients
- HbA1c > 7,5% for diet treated patients
- Age: 18 years or older
- 25 > BMI > 40 kg/m2
- Signed informed consent
- Sufficient birth control in case of child bearing capacity
Exclusion Criteria
- Proliferative retinopathy
- Diabetic nephropathy with s-creatinine > 130 microM and/or macroalbuminuria
- Liver disease (ALAT > 2 x normal value)
- CAD (NYHA group III or IV)
- Positive screening for islet-cell and/or GAD-65 autoantibodies
- Type 1 diabetes i first degree relatives
- Gastrointestinal surgery with intestinal resection
- Anemia
- Pregnancy and/or breastfeeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Insulin Secretion 0 - 90 minutes area under the curve AUC and insulin secretion rate
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Internal Medicine, Gentofte University Hospital
🇩🇰Hellerup, Copenhagen, Denmark