Frailty Status and Increased Risk for Falls: The Role of Anticholinergic Burden
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Frailty
- Sponsor
- Saglik Bilimleri Universitesi
- Enrollment
- 1000
- Locations
- 1
- Primary Endpoint
- Fall assessment
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
We hypothesized that the use of anticholinergic medications may precipitate falls differently by frailty status in older adults. Community-dwelling older subjects admitted to the Geriatrics Outpatient Clinic prospectively enter into the study. Frailty status is defined according to the Physical Frailty Phenotype. The drugs are categorized according to the ACB scale
Detailed Description
Previous studies have found that the use of drugs with anticholinergic properties relate to increased prevalence of falls in older women and men. Frailty is associated with serious health outcomes including falls, hip fractures, and death. Frailty can be a relevant target to investigate its association with the risk of falls among the users of drugs with anticholinergic properties. A recent evidence suggests that the interaction between being frail and adverse outcomes in older adults receiving polypharmacy or centrally acting drugs is complex and not straightforward across all frailty phenotypes. We classify the participants frail if they met at least three of five criteria, while those having one or two criteria were pre-frail, and others were non-frail. We determine the anticholinergic burden by using the Anticholinergic Cognitive Burden (ACB) Scale developed by Boustani et al.
Investigators
Mehmet Ilkin Naharci
Assoc.Prof.
Saglik Bilimleri Universitesi
Eligibility Criteria
Inclusion Criteria
- •Community-dwelling older adults
Exclusion Criteria
- •a history of dementia,
- •current delirium or psychotic symptoms,
- •taking antipsychotic medications,
- •being functionally dependent to others,
- •difficulty in communicating with the interviewer,
- •terminal illness,
- •being bedridden or wheelchair bound (≥2 weeks),
- •difficulty in standing or walking,
- •incomplete data
Outcomes
Primary Outcomes
Fall assessment
Time Frame: 1-2 hours
We will assess the association between anticholinergic burden (ACB) and falls based on frailty status among older adults.